What is the NOAEL for Rhein?
Rhein has 4 NOAEL studies in the database. The lowest reported value is YM64C2P6UX UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Rhein
Also known as: 1,8-dihydroxy-3-carboxyl anthraquinone, 4-10-00-04088, 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, BRN 2222155, Cassic acid (+9 more)
CAS 478-43-3
Rhein (CAS 478-43-3) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Rhein
CAS Number
478-43-3
DTXSID
DTXSID4026000
Molecular Formula
C15H8O6
InChI Key
FCDLCPWAQCPTKC-UHFFFAOYSA-N
Monoisotopic Mass
284.032088
Synonyms
1,8-dihydroxy-3-carboxyl anthraquinone4-10-00-040882-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-BRN 2222155Cassic acidChrysazin-3-carboxylic acid9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid1,8-Dihydroxyanthraquinone-3-carboxylic acidEINECS 207-521-4MonorheinNSC 38629Rheic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| YM64C2P6UX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YM64C2P6UX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YM64C2P6UX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YM64C2P6UX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid | 207-521-4 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
RHEIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
Frequently Asked Questions
What regulatory lists include Rhein?
Rhein appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Rhein used in cosmetics?
Yes, Rhein is also indexed as a cosmetic ingredient under the name Rhein. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Rhein come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Rhein used outside industrial chemicals?
Rhein also appears in cosmetics, pharmaceutical databases.