Warning GHS08GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)

CAS 474510-57-1

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) (CAS 474510-57-1) is a chemical substance with GHS signal word Warning; key hazard signal: H373 **; H400; H410. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for BIS-METHANE →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)

CAS Number

474510-57-1

DTXSID

DTXSID40621591

Molecular Formula

C21H24O4

InChI Key

PCKZAVNWRLEHIP-UHFFFAOYSA-N

Monoisotopic Mass

340.167459

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1	H373 **; H400; H410	GHS08; GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

UV stabilizerPhotosensitizers

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
=0.71	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
IZJ9BVRDO7	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZJ9BVRDO7	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZJ9BVRDO7	UNII	FDA UNII substance identifier	-	-	openFDA substances
IZJ9BVRDO7	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
<100	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
<200	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=5	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=30	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=90	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl)-2-methylpropan-1-one	444-860-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the GHS hazard classification for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) (CAS 474510-57-1) is classified under EU CLP Annex VI as STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H373 **; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one)?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) has 11 NOAEL studies in the database. The lowest reported value is 0.71 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

Is 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) used in cosmetics?

Yes, 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) is also indexed as a cosmetic ingredient under the name BIS-METHANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) used outside industrial chemicals?

1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one) also appears in cosmetics databases.