What is the NOAEL for Calcium carbonate?
Calcium carbonate has 14 NOAEL studies in the database. The lowest reported value is 6.36 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium carbonate
Also known as: Carbonic acid calcium salt (1:1), Calofor U 50, Caswell No. 139, CCC No.AA oolitic, EINECS 207-439-9 (+15 more)
CAS 471-34-1
Calcium carbonate (CAS 471-34-1) is a chemical substance. Key regulatory status: REACH registered, 45 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for Calcium Carbonate — Structured Cosmetic Ingre →
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
45
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Calcium carbonate
CAS Number
471-34-1
DTXSID
DTXSID3036238
Molecular Formula
CH2O3.Ca
InChI Key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
Monoisotopic Mass
101.962985
Synonyms
Carbonic acid calcium salt (1:1)Calofor U 50Caswell No. 139CCC No.AA ooliticEINECS 207-439-9EPA Pesticide Chemical Code 073502Eskalon 100Eskalon 1500Eskalon 200Eskalon 400Eskalon 800Garolite SA
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Short-term Effects | May cause mechanical irritation to the respiratory tract and eyes. |
| Long-term Effects | Health effects of the substance have been investigated but none have been found |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| NIOSH | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
| ACGIH | TWA | Withdrawn [2007] - Insufficient data. | - | - | - |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
AbrasiveAbsorbentDyeViscosity modifierpH regulating agentOpaciferFillerChelating agentAnti-adhesive/cohesivePigment
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
45 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Other direct contact consumer goods; residue | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | European Commission | CosIng |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 240 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =6.36 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H0G9379FGK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0G9379FGK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0G9379FGK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H0G9379FGK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6450 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 385 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1015 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1349 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 9989 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium carbonate | 207-439-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
35%
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CALCIUM CARBONATE
ChEMBL Phase
4
Adverse Events
16011
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E170 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium carbonate?
Calcium carbonate appears on 25 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 22 more. Source: EPA CPDat.
What are the occupational exposure limits for Calcium carbonate?
Occupational exposure limits for Calcium carbonate are set by OSHA, NIOSH, ACGIH. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Calcium carbonate used in cosmetics?
Yes, Calcium carbonate is also indexed as a cosmetic ingredient under the name Calcium Carbonate — Structured Cosmetic Ingre. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium carbonate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium carbonate used outside industrial chemicals?
Calcium carbonate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.