What is the NOAEL for Methylene glycol?
Methylene glycol has 18 NOAEL studies in the database. The lowest reported value is 6Z20YM9257 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Methylene glycol
Also known as: EINECS 207-339-5, UNII-6Z20YM9257, Methandiol, dihydroxymethane, formaldehyde hydrate (+1 more)
CAS 463-57-0
Methylene glycol (CAS 463-57-0) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Methylene glycol
CAS Number
463-57-0
DTXSID
DTXSID50196801
Molecular Formula
CH4O2
InChI Key
CKFGINPQOCXMAZ-UHFFFAOYSA-N
Monoisotopic Mass
48.021129
Synonyms
EINECS 207-339-5UNII-6Z20YM9257Methandioldihydroxymethaneformaldehyde hydratemethanediol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6Z20YM9257 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6Z20YM9257 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6Z20YM9257 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6Z20YM9257 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T0H3L6C7I5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T0H3L6C7I5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T0H3L6C7I5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T0H3L6C7I5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.08 | ppm | NOAEL | - | - | SCCS_vision_codex |
| =0.08 | ppm | NOAEL | - | - | SCCS_vision_codex |
| =0.08 | ppm | NOAEL | - | - | SCCS_vision_codex |
| =0.08 | ppm | NOAEL | - | - | SCCS_vision_codex |
| =1 | - | NOAEL | - | human | SCCS_vision_codex |
| =1 | - | NOAEL | - | human | SCCS_vision_codex |
| =1 | - | NOAEL | - | human | SCCS_vision_codex |
| =1 | - | NOAEL | - | human | SCCS_vision_codex |
| 0.08 | ppm | irritation | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1 | - | irritation | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 18 of 18 studies
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1470/12 | 26-27 June 2012 | not safe | Not safe in hair straightening products | Releases formaldehyde; classified CMR 1B carcinogen; linked to professional exposure hazards in Brazilian keratin treatments |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.2%
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL4285219
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Methylene glycol?
Methylene glycol appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is Methylene glycol used in cosmetics?
Yes, Methylene glycol is also indexed as a cosmetic ingredient under the name Methylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Methylene glycol used outside industrial chemicals?
Methylene glycol also appears in cosmetics, pharmaceutical, cannabis databases.