What is the NOAEL for 4-Isopropylcyclohexanol?
4-Isopropylcyclohexanol has 11 NOAEL studies in the database. The lowest reported value is 3N745V536F UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Isopropylcyclohexanol
Also known as: 4-iso-Propylcyclohexanol, p-Isopropylcyclohexanol, Cyclohexanol, 4-(1-methylethyl)-, Cyclohexanol, p-isopropyl-, 4-(1-Methylethyl)cyclohexanol (+6 more)
CAS 4621-04-9
4-Isopropylcyclohexanol (CAS 4621-04-9) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Isopropylcyclohexanol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
4-Isopropylcyclohexanol
CAS Number
4621-04-9
DTXSID
DTXSID2047149
Molecular Formula
C9H18O
InChI Key
DKKRDMLKVSKFMJ-UHFFFAOYSA-N
Monoisotopic Mass
142.135765
Synonyms
4-iso-Propylcyclohexanolp-IsopropylcyclohexanolCyclohexanol, 4-(1-methylethyl)-Cyclohexanol, p-isopropyl-4-(1-Methylethyl)cyclohexanol2-06-00-00035BRN 2322224EINECS 225-035-0NSC 21123Apo patchoneFolrosia
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3N745V536F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3N745V536F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3N745V536F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3N745V536F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 550 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3375 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2750 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-isopropylcyclohexanol | 225-035-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 4-Isopropylcyclohexanol?
4-Isopropylcyclohexanol appears on 2 regulatory/inventory lists including IFRA Transparency, consumer_product. Source: EPA CPDat.
Is 4-Isopropylcyclohexanol used in cosmetics?
Yes, 4-Isopropylcyclohexanol is also indexed as a cosmetic ingredient under the name Isopropylcyclohexanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Isopropylcyclohexanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Isopropylcyclohexanol have different safety status in cosmetics vs industrial chemicals?
4-Isopropylcyclohexanol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is 4-Isopropylcyclohexanol used outside industrial chemicals?
4-Isopropylcyclohexanol also appears in cosmetics databases.