What is the NOAEL for Ethylene glycol monoisobutyl ether?
Ethylene glycol monoisobutyl ether has 3 NOAEL studies in the database. The lowest reported value is 15 mg/kg bw/day via oral in Rat. Source: ECHA.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethylene glycol monoisobutyl ether
Also known as: 2-Isobutoxyethanol, Isobutyl cellosolve, Ethanol, 2-(2-methylpropoxy)-, BRN 1732707, EINECS 224-658-5 (+1 more)
CAS 4439-24-1
Ethylene glycol monoisobutyl ether (CAS 4439-24-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ethylene glycol monoisobutyl ether is classified GHS Danger (H226, H302, H311, H314, H318, H373, H319, H331) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
3
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Ethylene glycol monoisobutyl ether
CAS Number
4439-24-1
DTXSID
DTXSID3063469
Molecular Formula
C6H14O2
InChI Key
HHAPGMVKBLELOE-UHFFFAOYSA-N
Monoisotopic Mass
118.09938
Synonyms
2-IsobutoxyethanolIsobutyl cellosolveEthanol, 2-(2-methylpropoxy)-BRN 1732707EINECS 224-658-5Ektasolve EIB
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 3 of 3 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =400 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| ~15 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
Showing 3 of 3 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2-methylpropoxy)ethanol | 224-658-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
Is Ethylene glycol monoisobutyl ether used in cosmetics?
Yes, Ethylene glycol monoisobutyl ether is also indexed as a cosmetic ingredient under the name 2-Isobutylquinoline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethylene glycol monoisobutyl ether come from?
Safety data is sourced from EPA ToxValDB, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethylene glycol monoisobutyl ether have different safety status in cosmetics vs industrial chemicals?
Ethylene glycol monoisobutyl ether is classified GHS Danger (H226, H302, H311, H314, H318, H373, H319, H331) in the chemicals database but is allowed in EU cosmetics.
Is Ethylene glycol monoisobutyl ether used outside industrial chemicals?
Ethylene glycol monoisobutyl ether also appears in cosmetics databases.