Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Sodium dehydroacetate

Also known as: 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione sodium, Caswell No. 278A, Dehydroacetic acid, sodium salt, EINECS 224-580-1, EPA Pesticide Chemical Code 027802 (+8 more)

CAS 4418-26-2

Sodium dehydroacetate (CAS 4418-26-2) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Sodium Dehydroacetate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Sodium dehydroacetate

CAS Number

4418-26-2

DTXSID

DTXSID7026029

Molecular Formula

C8H8O4.Na

InChI Key

DSOWAKKSGYUMTF-GZOLSCHFSA-M

Synonyms

3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione sodiumCaswell No. 278ADehydroacetic acid, sodium saltEINECS 224-580-1EPA Pesticide Chemical Code 0278024-Hexenoic acid, 2-acetyl-5-hydroxy-3-oxo, delta-lactone, sodium derivative3-(1-Hydroxyethylidene)-6-methyl-2H-pyran-2,4(3H)-dione, sodium salt2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-, ion(1-), sodium salt2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-, sodium saltSodium 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dioneSodium 3-acetyl-6-methyl-2,4-pyrandioneKyselina dehydroacetova sodna sul

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *	H302	GHS07	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

PreservativeDye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=10.99	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
8W46YN971G	UNII	FDA UNII substance identifier	-	-	openFDA substances
8W46YN971G	UNII	FDA UNII substance identifier	-	-	openFDA substances
8W46YN971G	UNII	FDA UNII substance identifier	-	-	openFDA substances
8W46YN971G	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.062	fraction	Fu	-	Human	NTP_ICE_adme_parameters
-	unitless	Model Score	-	-	NTP_ICE_endocrine
46	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
50	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
124	mg/kg bw/day	NOAEL	oral	monkey	COSMOS_DB
428	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1000	mg/kg bw/day	NOEL	oral	Mouse	ToxValDB_ECOTOX

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Sodium 1-(3,4-dihydro-6-methyl-2,4-dioxo-2H-pyran-3-ylidene)ethanolate	224-580-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

20%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL SODIUM DEHYDROACETATE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0.6 mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Sodium dehydroacetate?

Sodium dehydroacetate (CAS 4418-26-2) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Sodium dehydroacetate?

Sodium dehydroacetate has 13 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Sodium dehydroacetate?

Sodium dehydroacetate appears on 3 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Europe; Personal care, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is Sodium dehydroacetate used in cosmetics?

Yes, Sodium dehydroacetate is also indexed as a cosmetic ingredient under the name Sodium Dehydroacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium dehydroacetate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Sodium dehydroacetate used outside industrial chemicals?

Sodium dehydroacetate also appears in cosmetics, pharmaceutical, food safety databases.