What is the NOAEL for 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone?
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone has 11 NOAEL studies in the database. The lowest reported value is UP5JTZ982I UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone
Also known as: alpha-Damascone, FEMA No. 3659, 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, 4-(2,6,6-Trimethyl-2-cyclohexenyl)-2-buten-4-one, UNII-UP5JTZ982I
CAS 43052-87-5
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone (CAS 43052-87-5) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone
CAS Number
43052-87-5
DTXSID
DTXSID0052097
Molecular Formula
C13H20O
InChI Key
CRIGTVCBMUKRSL-UHFFFAOYSA-N
Monoisotopic Mass
192.151415
Synonyms
alpha-DamasconeFEMA No. 36591-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one4-(2,6,6-Trimethyl-2-cyclohexenyl)-2-buten-4-oneUNII-UP5JTZ982I
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
9 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| UP5JTZ982I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UP5JTZ982I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UP5JTZ982I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UP5JTZ982I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 133 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 135 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =50 | mg/kg bw/day | LEL | oral | Chicken | EFSA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agen mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone?
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone used in cosmetics?
Yes, 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone is also indexed as a cosmetic ingredient under the name Alpha-Damascone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone used outside industrial chemicals?
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butenone also appears in cosmetics, food safety, cannabis databases.