What is the NOAEL for Calcium propionate?
Calcium propionate has 10 NOAEL studies in the database. The lowest reported value is 37.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium propionate
Also known as: Calcium dipropanoate, Propanoic acid, calcium salt (2:1), Propionic acid, calcium salt, Bioban-C, Calcium propanoate (+4 more)
CAS 4075-81-4
Calcium propionate (CAS 4075-81-4) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Calcium propionate is classified GHS Danger (H318) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Calcium propionate
CAS Number
4075-81-4
DTXSID
DTXSID1027556
Molecular Formula
2C3H6O2.Ca
InChI Key
BCZXFFBUYPCTSJ-UHFFFAOYSA-L
Monoisotopic Mass
188.03615
Synonyms
Calcium dipropanoatePropanoic acid, calcium salt (2:1)Propionic acid, calcium saltBioban-CCalcium propanoateCaswell No. 151EINECS 223-795-8EPA Pesticide Chemical Code 077701UNII-8AI80040KW
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
PreservativeDrierOtherBiocideAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =37.7 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8AI80040KW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AI80040KW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AI80040KW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AI80040KW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4 | % ae | LOEL | oral | Rat | ToxValDB_ECOTOX |
| 300 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 400 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 943 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =25000 | ppm | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium dipropionate | 223-795-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186661
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E282 — ADI: NOT LIMITED mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium propionate?
Calcium propionate appears on 5 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 2 more. Source: EPA CPDat.
Is Calcium propionate used in cosmetics?
Yes, Calcium propionate is also indexed as a cosmetic ingredient under the name Calcium Propionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium propionate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Calcium propionate have different safety status in cosmetics vs industrial chemicals?
Calcium propionate is classified GHS Danger (H318) in the chemicals database but is restricted in EU cosmetics.
Is Calcium propionate used outside industrial chemicals?
Calcium propionate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.