NOAEL Data REACH Registered Cosmetic Ingredient

Imidazolidinyl urea

Also known as: EINECS 254-372-6, UNII-M629807ATL, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea), methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol)

CAS 39236-46-9

Imidazolidinyl urea (CAS 39236-46-9) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Imidazolidinyl Urea →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
14
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
Imidazolidinyl urea
CAS Number
39236-46-9
DTXSID
DTXSID2040151
Molecular Formula
C11H16N8O8
InChI Key
ZCTXEAQXZGPWFG-UHFFFAOYSA-N
Monoisotopic Mass
388.10911
Synonyms
EINECS 254-372-6UNII-M629807ATLN,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol)

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 17 records
PreservativeProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records
ListKeywordSource
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Personal care - general moisturizingP&GProctor & Gamble
inert_ingredient; non_food_use; PesticidesEPACPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal careEuropean CommissionCosIng
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
57.238265050848uMAC50--NTP_ICE_endocrine
58.8503188856605uMACC--NTP_ICE_endocrine
39.3ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
7.921ug/mLCD86, EC120Dermal-NTP_ICE_skin_sensitization
11.2ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
11.43ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
42.3ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
28.46ug/mLCV70Dermal-NTP_ICE_skin_sensitization
40.1ug/mLCV75Dermal-NTP_ICE_skin_sensitization
55ug/mLCV75Dermal-NTP_ICE_skin_sensitization
7.5%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=24.5mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
3.8%Depletion CysDermal-NTP_ICE_skin_sensitization
40.9%Depletion CysDermal-NTP_ICE_skin_sensitization
47.8%Depletion CysDermal-NTP_ICE_skin_sensitization
48%Depletion CysDermal-NTP_ICE_skin_sensitization
52.3%Depletion CysDermal-NTP_ICE_skin_sensitization
55.9%Depletion CysDermal-NTP_ICE_skin_sensitization
58.5%Depletion CysDermal-NTP_ICE_skin_sensitization
59%Depletion CysDermal-NTP_ICE_skin_sensitization
0.9%Depletion LysDermal-NTP_ICE_skin_sensitization
1.3%Depletion LysDermal-NTP_ICE_skin_sensitization
14.6%Depletion LysDermal-NTP_ICE_skin_sensitization
15.9%Depletion LysDermal-NTP_ICE_skin_sensitization
17.1%Depletion LysDermal-NTP_ICE_skin_sensitization
20.6%Depletion LysDermal-NTP_ICE_skin_sensitization
21.1%Depletion LysDermal-NTP_ICE_skin_sensitization
25.7%Depletion LysDermal-NTP_ICE_skin_sensitization
2.4%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
26.8%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
27.75%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
31.85%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
33%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
38.5%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
39.8%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
42.1%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
18.58uMEC1.5Dermal-NTP_ICE_skin_sensitization
29.26uMEC1.5Dermal-NTP_ICE_skin_sensitization
29.9uMEC1.5Dermal-NTP_ICE_skin_sensitization
31.1uMEC1.5Dermal-NTP_ICE_skin_sensitization
31.22uMEC1.5Dermal-NTP_ICE_skin_sensitization
31.3uMEC1.5Dermal-NTP_ICE_skin_sensitization
31.44uMEC1.5Dermal-NTP_ICE_skin_sensitization
32.2uMEC1.5Dermal-NTP_ICE_skin_sensitization
32.38uMEC1.5Dermal-NTP_ICE_skin_sensitization
32.7uMEC1.5Dermal-NTP_ICE_skin_sensitization
32.97uMEC1.5Dermal-NTP_ICE_skin_sensitization
33.26uMEC1.5Dermal-NTP_ICE_skin_sensitization
33.32uMEC1.5Dermal-NTP_ICE_skin_sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredN,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]254-372-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.6%
Category
preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL IMIDUREA
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Imidazolidinyl urea?

Imidazolidinyl urea has 100 NOAEL studies in the database. The lowest reported value is 0.9 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Imidazolidinyl urea?

Imidazolidinyl urea appears on 10 regulatory/inventory lists including Europe; Personal care - body hygiene - hand soap, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 7 more. Source: EPA CPDat.

Is Imidazolidinyl urea used in cosmetics?

Yes, Imidazolidinyl urea is also indexed as a cosmetic ingredient under the name Imidazolidinyl Urea. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Imidazolidinyl urea come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Imidazolidinyl urea used outside industrial chemicals?

Imidazolidinyl urea also appears in cosmetics, pharmaceutical databases.