What is the NOAEL for 2-Phosphono-1,2,4-butanetricarboxylic acid?
2-Phosphono-1,2,4-butanetricarboxylic acid has 7 NOAEL studies in the database. The lowest reported value is 306P37319L UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phosphono-1,2,4-butanetricarboxylic acid
Also known as: 1,2,4-Butanetricarboxylic acid, 2-phosphono-, EINECS 253-733-5, 2-Phosphonobutane-1,2,4-tricarbonic acid, UNII-306P37319L
CAS 37971-36-1
2-Phosphono-1,2,4-butanetricarboxylic acid (CAS 37971-36-1) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for PHOSPHONOBUTANETRICARBOXYLIC ACID →
Cross-Vertical Regulatory Divergence
2-Phosphono-1,2,4-butanetricarboxylic acid is classified GHS Danger (H290, H314, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
2-Phosphono-1,2,4-butanetricarboxylic acid
CAS Number
37971-36-1
DTXSID
DTXSID4027999
Molecular Formula
C7H11O9P
InChI Key
SZHQPBJEOCHCKM-UHFFFAOYSA-N
Monoisotopic Mass
270.014069
Synonyms
1,2,4-Butanetricarboxylic acid, 2-phosphono-EINECS 253-733-52-Phosphonobutane-1,2,4-tricarbonic acidUNII-306P37319L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
Chelating agentpH regulating agentCorrosion inhibitor
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 306P37319L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 306P37319L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 306P37319L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 306P37319L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =4000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >6500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-phosphonobutane-1,2,4-tricarboxylic acid | 253-733-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Chelators
Frequently Asked Questions
What regulatory lists include 2-Phosphono-1,2,4-butanetricarboxylic acid?
2-Phosphono-1,2,4-butanetricarboxylic acid appears on 4 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, and 1 more. Source: EPA CPDat.
Is 2-Phosphono-1,2,4-butanetricarboxylic acid used in cosmetics?
Yes, 2-Phosphono-1,2,4-butanetricarboxylic acid is also indexed as a cosmetic ingredient under the name PHOSPHONOBUTANETRICARBOXYLIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phosphono-1,2,4-butanetricarboxylic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Phosphono-1,2,4-butanetricarboxylic acid have different safety status in cosmetics vs industrial chemicals?
2-Phosphono-1,2,4-butanetricarboxylic acid is classified GHS Danger (H290, H314, H319) in the chemicals database but is allowed in EU cosmetics.
Is 2-Phosphono-1,2,4-butanetricarboxylic acid used outside industrial chemicals?
2-Phosphono-1,2,4-butanetricarboxylic acid also appears in cosmetics databases.