What is the NOAEL for Tetrasodium etidronate?
Tetrasodium etidronate has 7 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetrasodium etidronate
Also known as: EINECS 223-267-7, Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt, (1-Hydroxyethylidene)diphosphonic acid, tetrasodium salt, UNII-CZZ9T1T1X4
CAS 3794-83-0
Tetrasodium etidronate (CAS 3794-83-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Tetrasodium etidronate is classified GHS Danger (H302, H319, H318, H413) in the chemicals database but is restricted in EU cosmetics at max 1.5%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Tetrasodium etidronate
CAS Number
3794-83-0
DTXSID
DTXSID7029663
Molecular Formula
C2H8O7P2.4Na
InChI Key
KWXLCDNSEHTOCB-UHFFFAOYSA-J
Monoisotopic Mass
297.933604
Synonyms
EINECS 223-267-7Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt(1-Hydroxyethylidene)diphosphonic acid, tetrasodium saltUNII-CZZ9T1T1X4
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
Chelating agentViscosity modifierEmulsifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =16.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| CZZ9T1T1X4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZZ9T1T1X4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZZ9T1T1X4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZZ9T1T1X4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =990 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrasodium (1-hydroxyethylidene)bisphosphonate | 223-267-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.5%
Category
Rheology Modifier
Frequently Asked Questions
What regulatory lists include Tetrasodium etidronate?
Tetrasodium etidronate appears on 3 regulatory/inventory lists including children; Europe; Personal care, Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe, Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe. Source: EPA CPDat.
Is Tetrasodium etidronate used in cosmetics?
Yes, Tetrasodium etidronate is also indexed as a cosmetic ingredient under the name Tetrasodium Etidronate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetrasodium etidronate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Tetrasodium etidronate have different safety status in cosmetics vs industrial chemicals?
Tetrasodium etidronate is classified GHS Danger (H302, H319, H318, H413) in the chemicals database but is restricted in EU cosmetics at max 1.5%.
Is Tetrasodium etidronate used outside industrial chemicals?
Tetrasodium etidronate also appears in cosmetics databases.