What is the NOAEL for Chlorhexidine dihydrochloride?
Chlorhexidine dihydrochloride has 4 NOAEL studies in the database. The lowest reported value is E64XL9U38K UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Chlorhexidine dihydrochloride
Also known as: Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, dihydrochloride, Caswell No. 481F, EINECS 223-026-6, EPA Pesticide Chemical Code 481700, 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochloride (+2 more)
CAS 3697-42-5
Chlorhexidine dihydrochloride (CAS 3697-42-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Chlorhexidine Dihydrochloride →
Cross-Vertical Regulatory Divergence
Chlorhexidine dihydrochloride is classified GHS Danger (H315, H319, H335, H373, H400, H410, H411, H317) in the chemicals database but is allowed in EU cosmetics at max 0.3%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Chlorhexidine dihydrochloride
CAS Number
3697-42-5
DTXSID
DTXSID7047144
Molecular Formula
C22H30Cl2N10.2ClH
InChI Key
WJLVQTJZDCGNJN-UHFFFAOYSA-N
Monoisotopic Mass
576.156552
Synonyms
Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, dihydrochlorideCaswell No. 481FEINECS 223-026-6EPA Pesticide Chemical Code 4817001,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochlorideChlorhexidine HClUNII-E64XL9U38K
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
8 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| E64XL9U38K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E64XL9U38K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E64XL9U38K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E64XL9U38K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chlorhexidine dihydrochloride | 223-026-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.3%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHLORHEXIDINE HYDROCHLORIDE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Chlorhexidine dihydrochloride?
Chlorhexidine dihydrochloride appears on 3 regulatory/inventory lists including active_ingredient; Australia, Canada; Personal care; Substances in PCP - Canada (4/2014), active_ingredient; Europe; Pesticides. Source: EPA CPDat.
Is Chlorhexidine dihydrochloride used in cosmetics?
Yes, Chlorhexidine dihydrochloride is also indexed as a cosmetic ingredient under the name Chlorhexidine Dihydrochloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chlorhexidine dihydrochloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chlorhexidine dihydrochloride have different safety status in cosmetics vs industrial chemicals?
Chlorhexidine dihydrochloride is classified GHS Danger (H315, H319, H335, H373, H400, H410, H411, H317) in the chemicals database but is allowed in EU cosmetics at max 0.3%.
Is Chlorhexidine dihydrochloride used outside industrial chemicals?
Chlorhexidine dihydrochloride also appears in cosmetics, pharmaceutical databases.