What is the NOAEL for (3Z)-3-Hexenyl acetate?
(3Z)-3-Hexenyl acetate has 17 NOAEL studies in the database. The lowest reported value is 11.75 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(3Z)-3-Hexenyl acetate
Also known as: z3HAC, 3-02-00-00287, BRN 1721854, EINECS 222-960-1, FEMA No. 3171 (+6 more)
CAS 3681-71-8
(3Z)-3-Hexenyl acetate (CAS 3681-71-8) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
(3Z)-3-Hexenyl acetate
CAS Number
3681-71-8
DTXSID
DTXSID0041484
Molecular Formula
C8H14O2
InChI Key
NPFVOOAXDOBMCE-PLNGDYQASA-N
Monoisotopic Mass
142.09938
Synonyms
z3HAC3-02-00-00287BRN 1721854EINECS 222-960-1FEMA No. 31713-Hexenyl acetate, (Z)-UNII-6INA6GC5I6(3Z)-hex-3-en-1-yl acetate(Z)-3-hexenol acetatecis-3-hexen-1-yl acetatecis-3-hexenyl ethanoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =11.75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6INA6GC5I6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6INA6GC5I6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6INA6GC5I6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6INA6GC5I6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =127 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (Z)-hex-3-enyl acetate | 222-960-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
(Z)-hex-3-en-1-yl acetate
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (3Z)-3-Hexenyl acetate?
(3Z)-3-Hexenyl acetate appears on 7 regulatory/inventory lists including SCIL (9/2019), air; detected; emissions; Personal care, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Is (3Z)-3-Hexenyl acetate used in cosmetics?
Yes, (3Z)-3-Hexenyl acetate is also indexed as a cosmetic ingredient under the name cis-3-Hexenyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (3Z)-3-Hexenyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (3Z)-3-Hexenyl acetate used outside industrial chemicals?
(3Z)-3-Hexenyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.