NOAEL Data REACH Registered Cosmetic Ingredient

D&C Red No. 33

Also known as: 2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium salt, D & C Red No. 33, C.I. Red 33, disodium salt, C.I. Reducing Agent 6, Disodium 2-phenylazo-3,5-naphthalenedisulfonate (+7 more)

CAS 3567-66-6

D&C Red No. 33 (CAS 3567-66-6) is a chemical substance. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Red 33 (CI 17200) →

SOURCE noael studies public
NOAEL studies
53
SOURCE chemical inventory jurisdictions
Regulatory lists
18
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields
Name
D&C Red No. 33
CAS Number
3567-66-6
DTXSID
DTXSID1044562
Molecular Formula
C16H13N3O7S2.2Na
InChI Key
LQJVOKWHGUAUHK-UHFFFAOYSA-L
Monoisotopic Mass
468.999031
Synonyms
2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium saltD & C Red No. 33C.I. Red 33, disodium saltC.I. Reducing Agent 6Disodium 2-phenylazo-3,5-naphthalenedisulfonateEdicol Supra 10BEdicol Supra 10BSEINECS 222-656-9NSC 12190NSC 5004Redusol ZUNII-9DBA0SBB0L

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - body hygiene - body washDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bubble bathDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
Personal careFDAUnited States Food and Drug Administration (FDA)
SCIL (9/2019)USEPASafer Chemical Ingredients List
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 53 studies
ValueUnitEndpointRouteSpeciesSource
25mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
102mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
9DBA0SBB0LUNIIFDA UNII substance identifier--openFDA substances
9DBA0SBB0LUNIIFDA UNII substance identifier--openFDA substances
9DBA0SBB0LUNIIFDA UNII substance identifier--openFDA substances
9DBA0SBB0LUNIIFDA UNII substance identifier--openFDA substances
=181mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
=750mg/kg bw/dayLOAELoralDogToxValDB_ECHA_IUCLID
=-mg/kg bwNOAELoralratSCCS_vision_codex
=-mg/kg bwNOAELoralratSCCS_vision_codex
=-mg/kg bwNOAELoralratSCCS_vision_codex
=-mg/kg bwNOAELoralratSCCS_vision_codex
=0.18mg/kgNOAELoralratSCCS_vision_codex
=0.18mg/kgNOAELoralratSCCS_vision_codex
=0.18mg/kgNOAELoralratSCCS_vision_codex
=0.18mg/kgNOAELoralratSCCS_vision_codex
=20mg/kg bw/dayNOAELdermalRabbitToxValDB_ECHA_IUCLID
=25mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=25mg/kg bw/dNOAELoralratSCCS_vision_codex
=25mg/kgNOAELoralratSCCS_vision_codex
=25mg/kg bw/dNOAELoralratSCCS_vision_codex
=25mg/kgNOAELoralratSCCS_vision_codex
=25mg/kg bw/dNOAELoralratSCCS_vision_codex
=25mg/kgNOAELoralratSCCS_vision_codex
=25mg/kg bw/dNOAELoralratSCCS_vision_codex
=25mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=102mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=102mg/kg bw/dNOAELoralratSCCS_vision_codex
=102mg/kg bwNOAEL-ratSCCS_vision_codex
=102mg/kg bw/dNOAELoralratSCCS_vision_codex
=102mg/kg bwNOAEL-ratSCCS_vision_codex
=102mg/kg bw/dNOAELoralratSCCS_vision_codex
=102mg/kg bwNOAEL-ratSCCS_vision_codex
=102mg/kg bw/dNOAELoralratSCCS_vision_codex
=102mg/kg bwNOAEL-ratSCCS_vision_codex
=129mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=129mg/kg bwNOAEL-ratSCCS_vision_codex
=129mg/kg bwNOAEL-ratSCCS_vision_codex
=129mg/kg bwNOAEL-ratSCCS_vision_codex
=129mg/kg bwNOAEL-ratSCCS_vision_codex
=150mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=1500mg/kg bw/dayNOAELdermalMouseToxValDB_ECHA_IUCLID
=2500mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=0.18mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=25mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=25mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
-mg/kg bwdevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg bw/ddevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg bw/ddevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 53 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredDisodium 5-amino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate222-656-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1112/0718 December 2007safe0.5%sensitisation potential not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.5%
Category
colorant
View full cosmetic safety profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

D&C Red 33 — 1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for D&C Red No. 33?

D&C Red No. 33 has 53 NOAEL studies in the database. The lowest reported value is 25 mg/kg bw/d via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include D&C Red No. 33?

D&C Red No. 33 appears on 13 regulatory/inventory lists including IFRA Transparency, Europe; Personal care - hair coloring, children; Europe; Personal care, and 10 more. Source: EPA CPDat.

Is D&C Red No. 33 used in cosmetics?

Yes, D&C Red No. 33 is also indexed as a cosmetic ingredient under the name Red 33 (CI 17200). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for D&C Red No. 33 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is D&C Red No. 33 used outside industrial chemicals?

D&C Red No. 33 also appears in cosmetics, food safety databases.