What is the NOAEL for Honokiol?
Honokiol has 4 NOAEL studies in the database. The lowest reported value is 11513CCO0N UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Honokiol
Also known as: 3',5-Diallyl-2,4'-biphenyldiol, 2-[4-Hydroxy-3-(2-propenyl)phenyl]-4-(2-propenyl)phenol, NSC 293100, UNII-11513CCO0N
CAS 35354-74-6
Honokiol (CAS 35354-74-6) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Honokiol is classified GHS Danger (H302, H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Honokiol
CAS Number
35354-74-6
DTXSID
DTXSID30188845
Molecular Formula
C18H18O2
InChI Key
FVYXIJYOAGAUQK-UHFFFAOYSA-N
Monoisotopic Mass
266.13068
Synonyms
3',5-Diallyl-2,4'-biphenyldiol2-[4-Hydroxy-3-(2-propenyl)phenyl]-4-(2-propenyl)phenolNSC 293100UNII-11513CCO0N
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
AntioxidantSoftener and conditionerBleaching agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 11513CCO0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11513CCO0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11513CCO0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11513CCO0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HONOKIOL
ChEMBL Phase
Not listed
Adverse Events
29
Bioactivity
8
Frequently Asked Questions
Is Honokiol used in cosmetics?
Yes, Honokiol is also indexed as a cosmetic ingredient under the name Honokiol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Honokiol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Honokiol have different safety status in cosmetics vs industrial chemicals?
Honokiol is classified GHS Danger (H302, H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
Is Honokiol used outside industrial chemicals?
Honokiol also appears in cosmetics, pharmaceutical databases.