What is the NOAEL for Propylparaben sodium?
Propylparaben sodium has 8 NOAEL studies in the database. The lowest reported value is 88.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propylparaben sodium
Also known as: Caswell No. 714A, EINECS 252-488-1, EPA Pesticide Chemical Code 061204, Propyl p-hydroxybenzoate, sodium salt, Natrium propyl 4-hydroxybenzoat (+5 more)
CAS 35285-69-9
Propylparaben sodium (CAS 35285-69-9) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Propylparaben sodium is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics at max 0.14%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
15 fields
Name
Propylparaben sodium
CAS Number
35285-69-9
DTXSID
DTXSID3042348
Molecular Formula
C10H12O3.Na
InChI Key
IXMINYBUNCWGER-UHFFFAOYSA-M
Synonyms
Caswell No. 714AEINECS 252-488-1EPA Pesticide Chemical Code 061204Propyl p-hydroxybenzoate, sodium saltNatrium propyl 4-hydroxybenzoatPropyl-4-hydroxybenzoat natriumsalzUNII-625NNB0G9NPropyl 4-hydroxybenzoate sodium saltSodium propyl hydroxybenzoateBenzoic acid, 4-hydroxy-, propyl ester, sodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
PreservativeBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =88.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 625NNB0G9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 625NNB0G9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 625NNB0G9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 625NNB0G9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =980.9 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1076.4 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1124.6 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 4-propoxycarbonylphenoxide | 252-488-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
0.14%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROPYLPARABEN SODIUM
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E217 — ADI: 10 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Propylparaben sodium?
Propylparaben sodium appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides. Source: EPA CPDat.
Is Propylparaben sodium used in cosmetics?
Yes, Propylparaben sodium is also indexed as a cosmetic ingredient under the name Sodium Propylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propylparaben sodium come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Propylparaben sodium have different safety status in cosmetics vs industrial chemicals?
Propylparaben sodium is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics at max 0.14%.
Is Propylparaben sodium used outside industrial chemicals?
Propylparaben sodium also appears in cosmetics, pharmaceutical, food safety databases.