What is the NOAEL for 1,7-Dioxacycloheptadecan-8-one?
1,7-Dioxacycloheptadecan-8-one has 4 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,7-Dioxacycloheptadecan-8-one
Also known as: 11-oxahexadecan-16-olide, Decanoic acid, 10-((5-hydroxypentyl)oxy)-, o-lactone, EINECS 222-225-5, 16-Hydroxy-11-oxahexadecanoic acid, omega-lactone, 11-Oxahexadecanolide
CAS 3391-83-1
1,7-Dioxacycloheptadecan-8-one (CAS 3391-83-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
1,7-Dioxacycloheptadecan-8-one
CAS Number
3391-83-1
DTXSID
DTXSID2052023
Molecular Formula
C15H28O3
InChI Key
MKEIDVFLAWJKMY-UHFFFAOYSA-N
Monoisotopic Mass
256.203845
Synonyms
11-oxahexadecan-16-olideDecanoic acid, 10-((5-hydroxypentyl)oxy)-, o-lactoneEINECS 222-225-516-Hydroxy-11-oxahexadecanoic acid, omega-lactone11-Oxahexadecanolide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 11-oxahexadecan-16-olide | 222-225-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 1,7-Dioxacycloheptadecan-8-one?
1,7-Dioxacycloheptadecan-8-one appears on 2 regulatory/inventory lists including IFRA Transparency, consumer_product. Source: EPA CPDat.
Is 1,7-Dioxacycloheptadecan-8-one used in cosmetics?
Yes, 1,7-Dioxacycloheptadecan-8-one is also indexed as a cosmetic ingredient under the name MUSK R1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,7-Dioxacycloheptadecan-8-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,7-Dioxacycloheptadecan-8-one used outside industrial chemicals?
1,7-Dioxacycloheptadecan-8-one also appears in cosmetics databases.