What is the NOAEL for N,N-Dimethyl-1-tetradecanamine N-oxide?
N,N-Dimethyl-1-tetradecanamine N-oxide has 9 NOAEL studies in the database. The lowest reported value is 6.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Dimethyl-1-tetradecanamine N-oxide
Also known as: N,N-Dimethylmyristylamine N-oxide, EINECS 222-059-3, UNII-J086PM3RRT
CAS 3332-27-2
N,N-Dimethyl-1-tetradecanamine N-oxide (CAS 3332-27-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N,N-Dimethyl-1-tetradecanamine N-oxide is classified GHS Danger (H302, H315, H318, H400, H410, H411, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
N,N-Dimethyl-1-tetradecanamine N-oxide
CAS Number
3332-27-2
DTXSID
DTXSID2029660
Molecular Formula
C16H35NO
InChI Key
ONHFWHCMZAJCFB-UHFFFAOYSA-N
Monoisotopic Mass
257.271865
Synonyms
N,N-Dimethylmyristylamine N-oxideEINECS 222-059-3UNII-J086PM3RRT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Solubility enhancerAnti-static agentEmulsifierCleaning agentSoftener and conditionerFoamantFragranceThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| J086PM3RRT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J086PM3RRT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J086PM3RRT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J086PM3RRT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1495 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N,N-dimethyltetradecylamine N-oxide | 222-059-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1782221
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include N,N-Dimethyl-1-tetradecanamine N-oxide?
N,N-Dimethyl-1-tetradecanamine N-oxide appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, SCIL (9/2019), IFRA Transparency. Source: EPA CPDat.
Is N,N-Dimethyl-1-tetradecanamine N-oxide used in cosmetics?
Yes, N,N-Dimethyl-1-tetradecanamine N-oxide is also indexed as a cosmetic ingredient under the name MYRISTAMINE OXIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyl-1-tetradecanamine N-oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Dimethyl-1-tetradecanamine N-oxide have different safety status in cosmetics vs industrial chemicals?
N,N-Dimethyl-1-tetradecanamine N-oxide is classified GHS Danger (H302, H315, H318, H400, H410, H411, H412) in the chemicals database but is allowed in EU cosmetics.
Is N,N-Dimethyl-1-tetradecanamine N-oxide used outside industrial chemicals?
N,N-Dimethyl-1-tetradecanamine N-oxide also appears in cosmetics, pharmaceutical databases.