NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

HC Blue 2

Also known as: HC Blue No. 2, BRN 2148848, EINECS 251-410-3, 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol), NCI-C54897 (+5 more)

CAS 33229-34-4

HC Blue 2 (CAS 33229-34-4) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.

View cosmetic safety profile for HC Blue No. 2 →

SOURCE noael studies public
NOAEL studies
52
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields
Name
HC Blue 2
CAS Number
33229-34-4
DTXSID
DTXSID6020193
Molecular Formula
C12H19N3O5
InChI Key
MIWUTEVJIISHCP-UHFFFAOYSA-N
Monoisotopic Mass
285.132471
Synonyms
HC Blue No. 2BRN 2148848EINECS 251-410-32,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)NCI-C548973-Nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-p-Phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-N(sup 1),N(sup 4),N(sup 4)-Tris(2-hydroxyethyl)-2-nitro-para-phenylenediamineUNII-6C0EL1931V2,2'-[[4-[(2-Hydroxyethyl)amino]-3-nitrophenyl]imino]bis-ethanol

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable199257

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 52 studies
ValueUnitEndpointRouteSpeciesSource
100mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
6C0EL1931VUNIIFDA UNII substance identifier--openFDA substances
6C0EL1931VUNIIFDA UNII substance identifier--openFDA substances
6C0EL1931VUNIIFDA UNII substance identifier--openFDA substances
6C0EL1931VUNIIFDA UNII substance identifier--openFDA substances
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
=0.0004mg/kgNOAELoralratSCCS_vision_codex
=0.0004mg/kgNOAELoralratSCCS_vision_codex
=0.0004mg/kgNOAELoralratSCCS_vision_codex
=0.0004mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=100mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=100mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=100mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=100mg/kgNOAELoralratSCCS_vision_codex
=100mg/kg/dayNOAELoralratSCCS_vision_codex
=300mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=300mg/kg/dayNOAEL--SCCS_vision_codex
=300mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=300mg/kg/dayNOAEL--SCCS_vision_codex
=300mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=300mg/kg/dayNOAEL--SCCS_vision_codex
=300mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=300mg/kg/dayNOAEL--SCCS_vision_codex
=300mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=1000mg/kg/dayNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELoralratSCCS_vision_codex
=1000mg/kg/dayNOAELoralratSCCS_vision_codex
=1000mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
10000ppmTop doseDosed feedRatNTP_ICE_cancer
20000ppmTop doseDosed feedMouseNTP_ICE_cancer
=0.0004mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=100mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=100mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
100mg/kg/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg/daydevelopmental toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg/daydevelopmental toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg/daydevelopmental toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 52 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2,2'-[[4-[(2-hydroxyethyl)amino]-3-nitrophenyl]imino]bisethanol251-410-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1000/0619 December 2006safe2.8%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
2.8%
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1561876
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for HC Blue 2?

HC Blue 2 has 52 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include HC Blue 2?

HC Blue 2 appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, children; Europe; Personal care. Source: EPA CPDat.

Is HC Blue 2 a carcinogen according to IARC?

HC Blue 2 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is HC Blue 2 used in cosmetics?

Yes, HC Blue 2 is also indexed as a cosmetic ingredient under the name HC Blue No. 2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Blue 2 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is HC Blue 2 used outside industrial chemicals?

HC Blue 2 also appears in cosmetics, pharmaceutical databases.