What is the NOAEL for 2H-Pyran-2-one, 6-butyltetrahydro-?
2H-Pyran-2-one, 6-butyltetrahydro- has 10 NOAEL studies in the database. The lowest reported value is DMB99B4WCF UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2H-Pyran-2-one, 6-butyltetrahydro-
Also known as: 5-Butyl-5-hydroxypentanoic acid lactone, delta-Nonalactone
CAS 3301-94-8
2H-Pyran-2-one, 6-butyltetrahydro- (CAS 3301-94-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
2H-Pyran-2-one, 6-butyltetrahydro-
CAS Number
3301-94-8
DTXSID
DTXSID70863149
Molecular Formula
C9H16O2
InChI Key
PXRBWNLUQYZAAX-UHFFFAOYSA-N
Monoisotopic Mass
156.11503
Synonyms
5-Butyl-5-hydroxypentanoic acid lactonedelta-Nonalactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| DMB99B4WCF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DMB99B4WCF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DMB99B4WCF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DMB99B4WCF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 6-butyltetrahydro-2H-pyran-2-one | 221-974-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2H-Pyran-2-one, 6-butyltetrahydro-?
2H-Pyran-2-one, 6-butyltetrahydro- appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe. Source: EPA CPDat.
Is 2H-Pyran-2-one, 6-butyltetrahydro- used in cosmetics?
Yes, 2H-Pyran-2-one, 6-butyltetrahydro- is also indexed as a cosmetic ingredient under the name Delta-Nonalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2H-Pyran-2-one, 6-butyltetrahydro- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2H-Pyran-2-one, 6-butyltetrahydro- used outside industrial chemicals?
2H-Pyran-2-one, 6-butyltetrahydro- also appears in cosmetics, food safety, cannabis databases.