What is the NOAEL for Alpha-Ketoglutaric acid?
Alpha-Ketoglutaric acid has 13 NOAEL studies in the database. The lowest reported value is 8ID597Z82X UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Alpha-Ketoglutaric acid
Also known as: Alphaketoglutaric acid, EINECS 206-330-3, Glutaric acid, alpha keto, alpha-Oxoglutaric acid, Bis(L-arginin)-2-oxoglutarat (+8 more)
CAS 328-50-7
Alpha-Ketoglutaric acid (CAS 328-50-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Alpha-Ketoglutaric acid is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
19 fields
Name
Alpha-Ketoglutaric acid
CAS Number
328-50-7
DTXSID
DTXSID5033179
Molecular Formula
C5H6O5
InChI Key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
Monoisotopic Mass
146.021523
Synonyms
Alphaketoglutaric acidEINECS 206-330-3Glutaric acid, alpha ketoalpha-Oxoglutaric acidBis(L-arginin)-2-oxoglutaratalpha KetoglutarateUNII-8ID597Z82Xalpha-Ketoglutaricum acidum2-Ketoglutarate2-Oxo-1,5-pentanedioate2-Oxoglutarate2-Oxopentanedioate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
DeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8ID597Z82X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8ID597Z82X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8ID597Z82X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8ID597Z82X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4.1 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 5.7 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 6.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 71.5 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 101.7 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 10.5 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 18.1 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 19.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-oxoglutaric acid | 206-330-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
ALPHA-KETOGLUTARIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Alpha-Ketoglutaric acid?
Alpha-Ketoglutaric acid appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Alpha-Ketoglutaric acid used in cosmetics?
Yes, Alpha-Ketoglutaric acid is also indexed as a cosmetic ingredient under the name Ketoglutaric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Ketoglutaric acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Alpha-Ketoglutaric acid have different safety status in cosmetics vs industrial chemicals?
Alpha-Ketoglutaric acid is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Is Alpha-Ketoglutaric acid used outside industrial chemicals?
Alpha-Ketoglutaric acid also appears in cosmetics, pharmaceutical, food safety databases.