What is the NOAEL for Piperonyl acetate?
Piperonyl acetate has 11 NOAEL studies in the database. The lowest reported value is 090XZ4C7VN UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Piperonyl acetate
Also known as: 1,3-Benzodioxole-5-methanol, 5-acetate, 4-19-00-00736, BRN 0384173, EINECS 206-312-5, FEMA No. 2912 (+6 more)
CAS 326-61-4
Piperonyl acetate (CAS 326-61-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
17 fields
Name
Piperonyl acetate
CAS Number
326-61-4
DTXSID
DTXSID2025925
Molecular Formula
C10H10O4
InChI Key
PFWYHTORQZAGCA-UHFFFAOYSA-N
Monoisotopic Mass
194.057909
Synonyms
1,3-Benzodioxole-5-methanol, 5-acetate4-19-00-00736BRN 0384173EINECS 206-312-5FEMA No. 2912Heliotropin acetateHeliotropyl acetate3,4-Methylenedioxybenzyl acetateNSC 406725Piperonyl alcohol, acetateUNII-090XZ4C7VN
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 090XZ4C7VN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 090XZ4C7VN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 090XZ4C7VN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 090XZ4C7VN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 4724 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2100 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Piperonyl acetate | 206-312-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL1366925
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Piperonyl acetate?
Piperonyl acetate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Piperonyl acetate used in cosmetics?
Yes, Piperonyl acetate is also indexed as a cosmetic ingredient under the name Piperonyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Piperonyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Piperonyl acetate used outside industrial chemicals?
Piperonyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.