What is the NOAEL for Octrizole?
Octrizole has 8 NOAEL studies in the database. The lowest reported value is 0.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
Octrizole
Also known as: Phenol, 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-, EINECS 221-573-5, Viosorb 583, Tinuvin 329, Sumisorb 340 (+15 more)
CAS 3147-75-9
Octrizole (CAS 3147-75-9) is a chemical substance; key hazard signal: vPvB (Article 57e). Key regulatory status: SVHC Candidate List, REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Octrizole
CAS Number
3147-75-9
DTXSID
DTXSID9027522
Molecular Formula
C20H25N3O
InChI Key
IYAZLDLPUNDVAG-UHFFFAOYSA-N
Monoisotopic Mass
323.199762
Synonyms
Phenol, 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-EINECS 221-573-5Viosorb 583Tinuvin 329Sumisorb 340Spectra-Sorb UV 5411Seesorb 709Cyasorb UV 5411Cyasorb 54112-(2'-Hydroxy-5'-tert-octylphenyl)benzotriazole2-(2'-Hydroxy-5'-tert-octylphenyl)benztriazole2-(2-Hydroxy-5-t-octylphenyl)-2H-benzotriazole
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol (UV-329) | vPvB (Article 57e) | 23-Jan-2024 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
UV stabilizerStabilizing agentFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5.87 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =0.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| R775Y233N3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R775Y233N3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R775Y233N3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R775Y233N3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0223 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol | 221-573-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
UV Filters
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OCTRIZOLE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Octrizole?
Octrizole appears on 7 regulatory/inventory lists including IFRA Transparency, consumer_product, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Is Octrizole a Substance of Very High Concern (SVHC)?
Yes, Octrizole is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: vPvB (Article 57e). Source: ECHA SVHC Candidate List.
Is Octrizole used in cosmetics?
Yes, Octrizole is also indexed as a cosmetic ingredient under the name OCTRIZOLE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octrizole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Octrizole used outside industrial chemicals?
Octrizole also appears in cosmetics, pharmaceutical databases.