Danger GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

5,6-Dihydroxyindole

Also known as: UNII-Z3OC8499KG, Dopamine lutine

CAS 3131-52-0

5,6-Dihydroxyindole (CAS 3131-52-0) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H318; H411. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for DIHYDROXYINDOLE →

SOURCE noael studies public
NOAEL studies
81
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
5,6-Dihydroxyindole
CAS Number
3131-52-0
DTXSID
DTXSID20185242
Molecular Formula
C8H7NO2
InChI Key
SGNZYJXNUURYCH-UHFFFAOYSA-N
Monoisotopic Mass
149.047678
Synonyms
UNII-Z3OC8499KGDopamine lutine

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Eye Dam. 1; Aquatic Chronic 2H302; H318; H411GHS07; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 81 studies
ValueUnitEndpointRouteSpeciesSource
1.5mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1.5mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg/day--ratUnifiedCodex:SCCNFP:beta.noael_studies
3mg/kg/day--ratUnifiedCodex:SCCNFP:beta.noael_studies
3mg/kg-oralratUnifiedCodex:SCCNFP:beta.noael_studies
3mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bw/day-oralratUnifiedCodex:SCCNFP:beta.noael_studies
10mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
Z3OC8499KGUNIIFDA UNII substance identifier--openFDA substances
Z3OC8499KGUNIIFDA UNII substance identifier--openFDA substances
Z3OC8499KGUNIIFDA UNII substance identifier--openFDA substances
Z3OC8499KGUNIIFDA UNII substance identifier--openFDA substances
10mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.012mg/kgNOAELdermalratSCCS_vision_codex
=0.012mg/kgNOAELdermalratSCCS_vision_codex
=0.012mg/kgNOAELdermalratSCCS_vision_codex
=0.012mg/kgNOAELdermalratSCCS_vision_codex
=1.5mg/kg bw/dNOAEL--SCCS_vision_codex
=1.5mg/kgNOAELdermalratSCCS_vision_codex
=1.5mg/kg bw/dNOAEL--SCCS_vision_codex
=1.5mg/kgNOAELdermalratSCCS_vision_codex
=1.5mg/kg bw/dNOAEL--SCCS_vision_codex
=1.5mg/kgNOAELdermalratSCCS_vision_codex
=1.5mg/kg bw/dNOAEL--SCCS_vision_codex
=1.5mg/kgNOAELdermalratSCCS_vision_codex
3mg/kg bw/dayNOAELoralratCOSMOS_DB
=3mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=3mg/kgNOAELoralratSCCNFP_vision_codex
=3mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=3mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=3mg/kgNOAELoralratSCCNFP_vision_codex
=3mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=3mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=3mg/kgNOAELoralratSCCNFP_vision_codex
=3mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=3mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=3mg/kgNOAELoralratSCCNFP_vision_codex
=3mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=10mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=10mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=10mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=10mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=10mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex

Showing 50 of 81 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered5,6-dihydroxyindole412-130-9ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0914/0528 March 2006insufficient data-insufficient genotoxicity and toxicological data

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
Annex III/207
Category
Hair Dyes
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL92636
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 5,6-Dihydroxyindole?

5,6-Dihydroxyindole (CAS 3131-52-0) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Dam. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H302; H318; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 5,6-Dihydroxyindole?

5,6-Dihydroxyindole has 81 NOAEL studies in the database. The lowest reported value is 0.012 mg/kg via dermal in rat. Source: SCCS_vision_codex.

What regulatory lists include 5,6-Dihydroxyindole?

5,6-Dihydroxyindole appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 5,6-Dihydroxyindole used in cosmetics?

Yes, 5,6-Dihydroxyindole is also indexed as a cosmetic ingredient under the name DIHYDROXYINDOLE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5,6-Dihydroxyindole come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 5,6-Dihydroxyindole have different safety status in cosmetics vs industrial chemicals?

5,6-Dihydroxyindole is prohibited in EU cosmetics at max Annex III/207 but has active industrial GHS classifications (H302, H318, H411).

Is 5,6-Dihydroxyindole used outside industrial chemicals?

5,6-Dihydroxyindole also appears in cosmetics, pharmaceutical databases.