Also known as: Oxiranemethanaminium, N,N,N-trimethyl-, chloride0, EINECS 221-221-0, beta,gamma-Epoxypropyltrimethylammonium chloride, (2,3-Epoxypropyl)trimethylammonium chloride, Glycidyl-trimethyl-ammonium chloride (+9 more)
CAS 3033-77-0
Glycidyl trimethylammonium chloride (CAS 3033-77-0) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H341; H361f ***; H312; H302; H373 **; H318; H317; H412. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE →
Glycidyl trimethylammonium chloride is classified GHS Danger (H350, H341, H361f, H312, H302, H373, H318, H317) in the chemicals database but is restricted in EU cosmetics at max II/1473.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 3 | H350; H341; H361f ***; H312; H302; H373 **; H318; H317; H412 | GHS08; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed or in contact with skin Causes serious eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Suspected of damaging fertility or the unborn child May cause damage to kidneys through prolonged or repeated exposure if swallowed Harmful to aquatic life with long lasting effects |
| Short-term Effects | The substance is severely irritating to the eyes and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body in hazardous amounts through the skin, by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 283XH39M8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 283XH39M8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 283XH39M8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 283XH39M8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.518 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| <3.16 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,3-epoxypropyltrimethylammonium chloride | 221-221-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Glycidyl trimethylammonium chloride (CAS 3033-77-0) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 3 with signal word Danger. Hazard statements: H350; H341; H361f ***; H312; H302; H373 **; H318; H317; H412. Source: EU CLP Annex VI (ECHA).
Glycidyl trimethylammonium chloride has 8 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
Glycidyl trimethylammonium chloride appears on 2 regulatory/inventory lists including banned; Europe; Personal care, Indirect additives food contact (10/2018). Source: EPA CPDat.
Yes, Glycidyl trimethylammonium chloride is also indexed as a cosmetic ingredient under the name 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Glycidyl trimethylammonium chloride is classified GHS Danger (H350, H341, H361f, H312, H302, H373, H318, H317) in the chemicals database but is restricted in EU cosmetics at max II/1473.
Glycidyl trimethylammonium chloride also appears in cosmetics, pharmaceutical databases.