What is the NOAEL for 5-Bromo-5-nitro-1,3-dioxane?
5-Bromo-5-nitro-1,3-dioxane has 13 NOAEL studies in the database. The lowest reported value is 0.0274 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
5-Bromo-5-nitro-1,3-dioxane
Also known as: 1,3-Dioxane, 5-bromo-5-nitro-, BRN 4668673, 5-Bromo-5-nitro-m-dioxane, Bronidox, EINECS 250-001-7 (+2 more)
CAS 30007-47-7
5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 5-Bromo-5-Nitro-1,3-Dioxane →
Cross-Vertical Regulatory Divergence
5-Bromo-5-nitro-1,3-dioxane is classified GHS Danger (H302, H314, H315, H317, H318, H373, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
5-Bromo-5-nitro-1,3-dioxane
CAS Number
30007-47-7
DTXSID
DTXSID1044560
Molecular Formula
C4H6BrNO4
InChI Key
XVBRCOKDZVQYAY-UHFFFAOYSA-N
Monoisotopic Mass
210.94802
Synonyms
1,3-Dioxane, 5-bromo-5-nitro-BRN 46686735-Bromo-5-nitro-m-dioxaneBronidoxEINECS 250-001-75-Brom-5-nitro-1,3-dioxanUNII-U184I9QBNM
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.0274 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| U184I9QBNM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U184I9QBNM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U184I9QBNM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U184I9QBNM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ~5 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| ~15 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =45 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | - | NOAEL | oral (gavage) | Wistar rat | CIR Safety Assessment |
| =50 | - | NOAEL | oral (gavage) | Wistar rat | CIR Safety Assessment |
| =50 | - | NOAEL | oral (gavage) | Wistar rat | CIR Safety Assessment |
| =50 | - | NOAEL | oral (gavage) | Wistar rat | CIR Safety Assessment |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 5-bromo-5-nitro-1,3-dioxane | 250-001-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.1%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3185787
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 5-Bromo-5-nitro-1,3-dioxane?
5-Bromo-5-nitro-1,3-dioxane appears on 5 regulatory/inventory lists including Europe; Personal care, children; Europe; Personal care - body hygiene - body wash, children; Europe; Personal care - specialized bath products - bubble bath, and 2 more. Source: EPA CPDat.
Is 5-Bromo-5-nitro-1,3-dioxane used in cosmetics?
Yes, 5-Bromo-5-nitro-1,3-dioxane is also indexed as a cosmetic ingredient under the name 5-Bromo-5-Nitro-1,3-Dioxane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 5-Bromo-5-nitro-1,3-dioxane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 5-Bromo-5-nitro-1,3-dioxane have different safety status in cosmetics vs industrial chemicals?
5-Bromo-5-nitro-1,3-dioxane is classified GHS Danger (H302, H314, H315, H317, H318, H373, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.1%.
Is 5-Bromo-5-nitro-1,3-dioxane used outside industrial chemicals?
5-Bromo-5-nitro-1,3-dioxane also appears in cosmetics, pharmaceutical databases.