What is the GHS hazard classification for Glyoxylic acid?
Glyoxylic acid (CAS 298-12-4) is classified under EU CLP Annex VI as Eye Dam. 1; Skin Sens. 1B with signal word Danger. Hazard statements: H318; H317. Source: EU CLP Annex VI (ECHA).
Danger
GHS05GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glyoxylic acid
Also known as: Acetic acid, oxo-, 4-03-00-01489, BRN 0741891, EINECS 206-058-5, Formic acid, formyl- (+14 more)
CAS 298-12-4
Glyoxylic acid (CAS 298-12-4) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H317. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Glyoxylic acid is classified GHS Danger (H318, H317) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Glyoxylic acid
CAS Number
298-12-4
DTXSID
DTXSID5021594
Molecular Formula
C2H2O3
InChI Key
HHLFWLYXYJOTON-UHFFFAOYSA-N
Monoisotopic Mass
74.000394
Synonyms
Acetic acid, oxo-4-03-00-01489BRN 0741891EINECS 206-058-5Formic acid, formyl-alpha-Ketoacetic acidKyselina glyoxylovaUNII-JQ39C92HH62-oxoacetic acidFormylformateGlyoxalsaeureGlyoxylate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Dam. 1; Skin Sens. 1B | H318; H317 | GHS05; GHS07 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Anti-static agentpH regulating agentHair waving or straightening
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =9.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| JQ39C92HH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ39C92HH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ39C92HH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ39C92HH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =6000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =18000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Glyoxylic acid | 206-058-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLYOXYLATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for Glyoxylic acid?
Glyoxylic acid has 12 NOAEL studies in the database. The lowest reported value is 5.3 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
What regulatory lists include Glyoxylic acid?
Glyoxylic acid appears on 4 regulatory/inventory lists including pharmaceutical, CEDI, active_ingredient; Europe; Pesticides, and 1 more. Source: EPA CPDat.
Is Glyoxylic acid used in cosmetics?
Yes, Glyoxylic acid is also indexed as a cosmetic ingredient under the name Glyoxylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glyoxylic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Glyoxylic acid have different safety status in cosmetics vs industrial chemicals?
Glyoxylic acid is classified GHS Danger (H318, H317) in the chemicals database but is allowed in EU cosmetics.
Is Glyoxylic acid used outside industrial chemicals?
Glyoxylic acid also appears in cosmetics, pharmaceutical databases.