NOAEL Data Cosmetic Ingredient

5,6-Dihydroxyindoline

Also known as: 1H -Indole-5,6-diol, 2,3-dihydro-, 2,3-Dihydro-1H -indole-5,6-diol, 5,6-Indolinediol, Leucodopaminochrome

CAS 29539-03-5

5,6-Dihydroxyindoline (CAS 29539-03-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Dihydroxyindoline →

SOURCE noael studies public
NOAEL studies
43
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
5,6-Dihydroxyindoline
CAS Number
29539-03-5
DTXSID
DTXSID80865492
Molecular Formula
C8H9NO2
InChI Key
VGSVNUGKHOVSPK-UHFFFAOYSA-N
Monoisotopic Mass
151.063329
Synonyms
1H -Indole-5,6-diol, 2,3-dihydro-2,3-Dihydro-1H -indole-5,6-diol5,6-IndolinediolLeucodopaminochrome

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 43 of 43 studies
ValueUnitEndpointRouteSpeciesSource
20mg/kg bw/day--ratUnifiedCodex:SCCNFP:beta.noael_studies
20mg/kg bw/day--ratUnifiedCodex:SCCNFP:beta.noael_studies
180mg/kg bw/day--ratUnifiedCodex:SCCNFP:beta.noael_studies
HH49N58FJ9UNIIFDA UNII substance identifier--openFDA substances
HH49N58FJ9UNIIFDA UNII substance identifier--openFDA substances
HH49N58FJ9UNIIFDA UNII substance identifier--openFDA substances
HH49N58FJ9UNIIFDA UNII substance identifier--openFDA substances
20mg/kg bw/dayLOAELoralratCOSMOS_DB
=2%NOAELoralratSCCNFP_vision_codex
=2%NOAELoralratSCCNFP_vision_codex
=2%NOAELoralratSCCNFP_vision_codex
=2%NOAELoralratSCCNFP_vision_codex
10mg/kg bw/dayNOAELoralratCOSMOS_DB
=10mg/kg/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kgNOAELoralratSCCNFP_vision_codex
=10mg/kg bw/dayNOAELoralratSCCNFP_vision_codex
=10mg/kg/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kgNOAELoralratSCCNFP_vision_codex
=10mg/kg bw/dayNOAELoralratSCCNFP_vision_codex
=10mg/kg/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kgNOAELoralratSCCNFP_vision_codex
=10mg/kg bw/dayNOAELoralratSCCNFP_vision_codex
=10mg/kg/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kgNOAELoralratSCCNFP_vision_codex
=10mg/kg bw/dayNOAELoralratSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=240mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=240mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=240mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=240mg/kg bw/dayNOAELdermalratSCCNFP_vision_codex
=10mg/kgdermal absorptionoralratUnifiedCodex:SCCNFP:beta.noael_studies
=10mg/kgdermal absorptionoralratUnifiedCodex:SCCNFP:beta.noael_studies
240mg/kg bw/daydermal absorptiondermalratUnifiedCodex:SCCNFP:beta.noael_studies
2%repeated dose toxicityoralratUnifiedCodex:SCCNFP:beta.noael_studies
10mg/kg/dayrepeated dose toxicitydermalratUnifiedCodex:SCCNFP:beta.noael_studies
10mg/kg bw/dayrepeated dose toxicityoralratUnifiedCodex:SCCNFP:beta.noael_studies

Showing 43 of 43 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 5,6-Dihydroxyindoline?

5,6-Dihydroxyindoline has 43 NOAEL studies in the database. The lowest reported value is 20 mg/kg bw/day in rat. Source: UnifiedCodex:SCCNFP:beta.noael_studies.

Is 5,6-Dihydroxyindoline used in cosmetics?

Yes, 5,6-Dihydroxyindoline is also indexed as a cosmetic ingredient under the name Dihydroxyindoline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5,6-Dihydroxyindoline come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 5,6-Dihydroxyindoline used outside industrial chemicals?

5,6-Dihydroxyindoline also appears in cosmetics databases.