What is the NOAEL for Methyl benzodioxepinone?
Methyl benzodioxepinone has 8 NOAEL studies in the database. The lowest reported value is 0NQ136C313 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methyl benzodioxepinone
Also known as: Calone, Watermelon Ketone, 7-Methyl-2H-1,5-benzodioxepin-3(4H)-one, 2H-1,5-Benzodioxepin-3(4H)-one, 7-methyl-, EINECS 249-320-4 (+2 more)
CAS 28940-11-6
Methyl benzodioxepinone (CAS 28940-11-6) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Methyl benzodioxepinone
CAS Number
28940-11-6
DTXSID
DTXSID0047165
Molecular Formula
C10H10O3
InChI Key
SWUIQEBPZIHZQS-UHFFFAOYSA-N
Monoisotopic Mass
178.062994
Synonyms
CaloneWatermelon Ketone7-Methyl-2H-1,5-benzodioxepin-3(4H)-one2H-1,5-Benzodioxepin-3(4H)-one, 7-methyl-EINECS 249-320-47-Methyl-3,4-dihydro-2H-1,5-benzodioxepin-3-oneUNII-0NQ136C313
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DeodorizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0NQ136C313 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NQ136C313 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NQ136C313 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0NQ136C313 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=791 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=887 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=922 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=15000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 7-methyl-2H-benzo-1,5-dioxepin-3(4H)-one | 249-320-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3187905
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Methyl benzodioxepinone?
Methyl benzodioxepinone appears on 2 regulatory/inventory lists including IFRA Transparency, SCIL (9/2019). Source: EPA CPDat.
Is Methyl benzodioxepinone used in cosmetics?
Yes, Methyl benzodioxepinone is also indexed as a cosmetic ingredient under the name Methyl Benzodioxepinone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl benzodioxepinone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Methyl benzodioxepinone used outside industrial chemicals?
Methyl benzodioxepinone also appears in cosmetics, pharmaceutical databases.