What is the NOAEL for C.I. Direct Yellow 12?
C.I. Direct Yellow 12 has 8 NOAEL studies in the database. The lowest reported value is 7.31970397 uM. Source: NTP ICE endocrine.
NOAEL Data
Cosmetic Ingredient
C.I. Direct Yellow 12
Also known as: Chrysophenine, Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[2-(4-ethoxyphenyl)diazenyl]-, sodium salt (1:2), 4,4'-Bis((p-ethoxyphenyl)azo)-2,2'-stilbenesulfonic acid disodium salt, Disodium 4,4'-bis((4-ethoxyphenyl)azo)stilbene-2,2'-disulphonate, Airedale Yellow CHD (+15 more)
CAS 2870-32-8
C.I. Direct Yellow 12 (CAS 2870-32-8) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Direct Yellow 12
CAS Number
2870-32-8
DTXSID
DTXSID5041728
Molecular Formula
C30H28N4O8S2.2Na
InChI Key
YQMJDPHTMKUEHG-UHFFFAOYSA-L
Monoisotopic Mass
682.114395
Synonyms
ChrysophenineBenzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[2-(4-ethoxyphenyl)diazenyl]-, sodium salt (1:2)4,4'-Bis((p-ethoxyphenyl)azo)-2,2'-stilbenesulfonic acid disodium saltDisodium 4,4'-bis((4-ethoxyphenyl)azo)stilbene-2,2'-disulphonateAiredale Yellow CHDAmanil Chrysophenine GAtlantic Chrysophenine YAAurophenine OBenzanil Yellow CHBenzo Yellow LGCalcomine Brilliant YellowChrome Leather Yellow CH
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 11.79084283 | uM | AC50 | - | - | NTP ICE endocrine |
| 7.31970397 | uM | ACC | - | - | NTP ICE endocrine |
| 8Q5531T139 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q5531T139 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q5531T139 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q5531T139 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0716 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include C.I. Direct Yellow 12?
C.I. Direct Yellow 12 appears on 2 regulatory/inventory lists including banned; Europe; Personal care, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is C.I. Direct Yellow 12 used in cosmetics?
Yes, C.I. Direct Yellow 12 is also indexed as a cosmetic ingredient under the name Direct Yellow 12. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Direct Yellow 12 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is C.I. Direct Yellow 12 used outside industrial chemicals?
C.I. Direct Yellow 12 also appears in cosmetics databases.