What is the NOAEL for 2-Methyl-3-furanthiol?
2-Methyl-3-furanthiol has 37 NOAEL studies in the database. The lowest reported value is N21RW1N179 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2-Methyl-3-furanthiol
Also known as: 3-Furanthiol, 2-methyl-, 2-Methylfuran-3-thiol, EINECS 249-094-7, FEMA No. 3188, 2-Methyl-3-furylmercaptan (+3 more)
CAS 28588-74-1
2-Methyl-3-furanthiol (CAS 28588-74-1) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
2-Methyl-3-furanthiol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H318, H330).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
37
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2-Methyl-3-furanthiol
CAS Number
28588-74-1
DTXSID
DTXSID5047118
Molecular Formula
C5H6OS
InChI Key
RUYNUXHHUVUINQ-UHFFFAOYSA-N
Monoisotopic Mass
114.013936
Synonyms
3-Furanthiol, 2-methyl-2-Methylfuran-3-thiolEINECS 249-094-7FEMA No. 31882-Methyl-3-furylmercaptan2-Methyl-3-furylthiol2-Methyl-3-mercaptofuranUNII-N21RW1N179
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 37 of 37 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| N21RW1N179 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N21RW1N179 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N21RW1N179 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N21RW1N179 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =5 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.45 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.45 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.56 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.56 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.73 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.73 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.74 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.74 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.83 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =0.83 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.2 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.2 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.4 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.4 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.7 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =1.7 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =3.8 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =3.8 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =5 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =5 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =5 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =8.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =8.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =10 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =10 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =17 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
| =17 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v50je13 |
Showing 37 of 37 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188696
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methyl-3-furanthiol?
2-Methyl-3-furanthiol appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe. Source: EPA CPDat.
Is 2-Methyl-3-furanthiol used in cosmetics?
Yes, 2-Methyl-3-furanthiol is also indexed as a cosmetic ingredient under the name 2-Methylfuran-3-Thiol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methyl-3-furanthiol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methyl-3-furanthiol have different safety status in cosmetics vs industrial chemicals?
2-Methyl-3-furanthiol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H318, H330).
Is 2-Methyl-3-furanthiol used outside industrial chemicals?
2-Methyl-3-furanthiol also appears in cosmetics, pharmaceutical, cannabis databases.