NOAEL Data Cosmetic Ingredient

1,4-Benzenediamine, 2-nitro-N1-phenyl-

Also known as: EINECS 220-494-3, HC Red No. 1, 2-Nitro-4-aminodiphenylamine, 2-Nitro-N1-phenyl-1,4-benzenediamine, 2-Nitro-N(sup 1)-phenyl-1,4-benzenediamine (+2 more)

CAS 2784-89-6

1,4-Benzenediamine, 2-nitro-N1-phenyl- (CAS 2784-89-6) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for HC RED NO. 1 →

SOURCE noael studies public
NOAEL studies
46
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
1,4-Benzenediamine, 2-nitro-N1-phenyl-
CAS Number
2784-89-6
DTXSID
DTXSID4062640
Molecular Formula
C12H11N3O2
InChI Key
WHJNKCNHEVCICH-UHFFFAOYSA-N
Monoisotopic Mass
229.085127
Synonyms
EINECS 220-494-3HC Red No. 12-Nitro-4-aminodiphenylamine2-Nitro-N1-phenyl-1,4-benzenediamine2-Nitro-N(sup 1)-phenyl-1,4-benzenediaminep-Phenylenediamine, 2-nitro-N(sup 1)-phenyl-UNII-1FZM1701IS

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies
ValueUnitEndpointRouteSpeciesSource
5mg/kg bw/d-oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
20mg/kg bw/d-oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
20mg/kg bw/d-oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1FZM1701ISUNIIFDA UNII substance identifier--openFDA substances
1FZM1701ISUNIIFDA UNII substance identifier--openFDA substances
1FZM1701ISUNIIFDA UNII substance identifier--openFDA substances
1FZM1701ISUNIIFDA UNII substance identifier--openFDA substances
2mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.0294mg/kgNOAELoralratSCCS_vision_codex
=0.0294mg/kgNOAELoralratSCCS_vision_codex
=0.0294mg/kgNOAELoralratSCCS_vision_codex
=0.0294mg/kgNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=5mg/kgNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=5mg/kgNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=5mg/kgNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=5mg/kgNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=20mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=20mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=20mg/kg bw/dNOAELoralrabbitSCCS_vision_codex
=25mg/kg/dayNOAELoral-SCCS_vision_codex
=25mg/kg/dayNOAELoral-SCCS_vision_codex
=25mg/kg/dayNOAELoral-SCCS_vision_codex
=25mg/kg/dayNOAELoral-SCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dNOAELoralratSCCS_vision_codex
=125mg/kg bw/dNOAEL--SCCS_vision_codex
=125mg/kg bw/dNOAEL--SCCS_vision_codex
=125mg/kg bw/dNOAEL--SCCS_vision_codex
=125mg/kg bw/dNOAEL--SCCS_vision_codex
25mg/kg/daydevelopmental toxicityoral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
125mg/kg bw/ddevelopmental toxicity--UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.0294mg/kgrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=5mg/kgrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=5mg/kgrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
5mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/drepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
125mg/kg bw/drepeated dose toxicitydermalmouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 46 of 46 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0979/0610 October 2006safe1.0%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
Annex III/258
Category
Hair Dyes
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 1,4-Benzenediamine, 2-nitro-N1-phenyl-?

1,4-Benzenediamine, 2-nitro-N1-phenyl- has 46 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/d via oral in rabbit. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include 1,4-Benzenediamine, 2-nitro-N1-phenyl-?

1,4-Benzenediamine, 2-nitro-N1-phenyl- appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 1,4-Benzenediamine, 2-nitro-N1-phenyl- used in cosmetics?

Yes, 1,4-Benzenediamine, 2-nitro-N1-phenyl- is also indexed as a cosmetic ingredient under the name HC RED NO. 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,4-Benzenediamine, 2-nitro-N1-phenyl- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,4-Benzenediamine, 2-nitro-N1-phenyl- have different safety status in cosmetics vs industrial chemicals?

1,4-Benzenediamine, 2-nitro-N1-phenyl- is prohibited in EU cosmetics at max Annex III/258 but has active industrial GHS classifications (H302, H317, H319).

Is 1,4-Benzenediamine, 2-nitro-N1-phenyl- used outside industrial chemicals?

1,4-Benzenediamine, 2-nitro-N1-phenyl- also appears in cosmetics databases.