What is the NOAEL for Prop-2-en-1-yl 3-cyclohexylpropanoate?
Prop-2-en-1-yl 3-cyclohexylpropanoate has 12 NOAEL studies in the database. The lowest reported value is 21.13 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Prop-2-en-1-yl 3-cyclohexylpropanoate
Also known as: Cyclohexanepropanoic acid, 2-propenyl ester, Allyl cyclohexylpropanoate, 4-09-00-00056, Allyl beta-cyclohexylpropionate, Allyl hexahydrophenylpropionate (+10 more)
CAS 2705-87-5
Prop-2-en-1-yl 3-cyclohexylpropanoate (CAS 2705-87-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Allyl Cyclohexylpropionate →
Cross-Vertical Regulatory Divergence
Prop-2-en-1-yl 3-cyclohexylpropanoate is classified GHS Danger (H302, H312, H315, H317, H332, H400, H410, H301) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
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eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
21 fields
Name
Prop-2-en-1-yl 3-cyclohexylpropanoate
CAS Number
2705-87-5
DTXSID
DTXSID8044755
Molecular Formula
C12H20O2
InChI Key
TWXUTZNBHUWMKJ-UHFFFAOYSA-N
Monoisotopic Mass
196.14633
Synonyms
Cyclohexanepropanoic acid, 2-propenyl esterAllyl cyclohexylpropanoate4-09-00-00056Allyl beta-cyclohexylpropionateAllyl hexahydrophenylpropionate3-Allylcyclohexyl propionateBRN 2254663Cyclohexanol, 3-allyl-, propionateEINECS 220-292-5FEMA No. 20262-Propenyl cyclohexanepropanoate2-Propen-1-yl cyclohexanepropionate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =21.13 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H4W9H3L241 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H4W9H3L241 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H4W9H3L241 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H4W9H3L241 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =585 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Allyl 3-cyclohexylpropionate | 220-292-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3184129
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Prop-2-en-1-yl 3-cyclohexylpropanoate?
Prop-2-en-1-yl 3-cyclohexylpropanoate appears on 5 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Prop-2-en-1-yl 3-cyclohexylpropanoate used in cosmetics?
Yes, Prop-2-en-1-yl 3-cyclohexylpropanoate is also indexed as a cosmetic ingredient under the name Allyl Cyclohexylpropionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Prop-2-en-1-yl 3-cyclohexylpropanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Prop-2-en-1-yl 3-cyclohexylpropanoate have different safety status in cosmetics vs industrial chemicals?
Prop-2-en-1-yl 3-cyclohexylpropanoate is classified GHS Danger (H302, H312, H315, H317, H332, H400, H410, H301) in the chemicals database but is restricted in EU cosmetics.
Is Prop-2-en-1-yl 3-cyclohexylpropanoate used outside industrial chemicals?
Prop-2-en-1-yl 3-cyclohexylpropanoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.