Also known as: N-Lauryl-2-pyrrolidone, BRN 0155011, N-Dodecylpyrrolidinone, UNII-3P14VW8FNY
CAS 2687-96-9
1-Dodecyl-2-pyrrolidinone (CAS 2687-96-9) is a chemical substance with GHS signal word Danger; key hazard signal: H314; H317; H400; H410. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
1-Dodecyl-2-pyrrolidinone is prohibited in EU cosmetics but has active industrial GHS classifications (H314, H317, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H314; H317; H400; H410 | GHS05; GHS07; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 117.892868514905 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 75.2912585621506 | uM | ACC | - | - | NTP_ICE_endocrine |
| 19.1 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =7.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3P14VW8FNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P14VW8FNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P14VW8FNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3P14VW8FNY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0125 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =90 | mg/kg bw/day | LOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0135 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =30 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =57.6 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-(n-dodecyl)pyrrolidinone | 403-730-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
1-Dodecyl-2-pyrrolidinone (CAS 2687-96-9) is classified under EU CLP Annex VI as Skin Corr. 1B; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H314; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
1-Dodecyl-2-pyrrolidinone has 14 NOAEL studies in the database. The lowest reported value is 7.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
1-Dodecyl-2-pyrrolidinone appears on 1 regulatory/inventory list including inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Yes, 1-Dodecyl-2-pyrrolidinone is also indexed as a cosmetic ingredient under the name Lauryl Pyrrolidone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
1-Dodecyl-2-pyrrolidinone is prohibited in EU cosmetics but has active industrial GHS classifications (H314, H317, H400, H410).
1-Dodecyl-2-pyrrolidinone also appears in cosmetics, pharmaceutical databases.