What is the NOAEL for Sorbitan tristearate?
Sorbitan tristearate has 12 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sorbitan tristearate
Also known as: (Sorbitan tristearate), Span(R) 65, EINECS 247-891-4, Sorbitani tristearas, UNII-6LUM696811
CAS 26658-19-5
Sorbitan tristearate (CAS 26658-19-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Sorbitan tristearate
CAS Number
26658-19-5
DTXSID
DTXSID8047054
Molecular Formula
C60H114O8
InChI Key
IJCWFDPJFXGQBN-RYNSOKOISA-N
Monoisotopic Mass
962.851371
Synonyms
(Sorbitan tristearate)Span(R) 65EINECS 247-891-4Sorbitani tristearasUNII-6LUM696811
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
EmulsifierSurfactant (surface active agent)Dispersing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 6LUM696811 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LUM696811 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LUM696811 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LUM696811 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >15900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1600 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =2600 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_EFSA |
| =2600 | mg/kg bw/day | NOAEL | oral: feed | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sorbitan tristearate | 247-891-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E492 — ADI: 25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sorbitan tristearate?
Sorbitan tristearate appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Is Sorbitan tristearate used in cosmetics?
Yes, Sorbitan tristearate is also indexed as a cosmetic ingredient under the name SORBITAN TRISTEARATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sorbitan tristearate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Sorbitan tristearate used outside industrial chemicals?
Sorbitan tristearate also appears in cosmetics, food safety, cannabis databases.