What is the NOAEL for Topilutamide?
Topilutamide has 4 NOAEL studies in the database. The lowest reported value is A8EU2FXY13 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Topilutamide
Also known as: 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(2,2,2-trifluoroacetamido)propanamide, Fluridil, Propanamide, 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]-, BP 766
CAS 260980-89-0
Topilutamide (CAS 260980-89-0) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Topilutamide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Topilutamide
CAS Number
260980-89-0
DTXSID
DTXSID30870298
Molecular Formula
C13H11F6N3O5
InChI Key
YCNCRLKXSLARFT-UHFFFAOYNA-N
Monoisotopic Mass
403.060289444
Synonyms
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(2,2,2-trifluoroacetamido)propanamideFluridilPropanamide, 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]-BP 766
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | - | https://hts.usitc.gov/view/list |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| A8EU2FXY13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A8EU2FXY13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A8EU2FXY13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A8EU2FXY13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Hair Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TOPILUTAMIDE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Topilutamide?
Topilutamide appears on 1 regulatory/inventory list including pharmaceutical. Source: EPA CPDat.
Is Topilutamide used in cosmetics?
Yes, Topilutamide is also indexed as a cosmetic ingredient under the name Fluridil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Topilutamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Topilutamide have different safety status in cosmetics vs industrial chemicals?
Topilutamide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H411).
Is Topilutamide used outside industrial chemicals?
Topilutamide also appears in cosmetics, pharmaceutical databases.