NOAEL Data REACH Registered Cosmetic Ingredient

Allura Red C.I.16035

Also known as: 2-Naphthalenesulfonic acid, 6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfophenyl)azo]-, disodium salt, FD&C Red no.40, C.I. Food Red 17, C. I. 16035, Allura Red AC Dye (+7 more)

CAS 25956-17-6

Allura Red C.I.16035 (CAS 25956-17-6) is a chemical substance. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for CI 16035 (Allura Red AC) →

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Allura Red C.I.16035

CAS Number

25956-17-6

DTXSID

DTXSID4024436

Molecular Formula

C18H16N2O8S2.2Na

InChI Key

CEZCCHQBSQPRMU-LLIZZRELSA-L

Monoisotopic Mass

498.014346

Synonyms

2-Naphthalenesulfonic acid, 6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfophenyl)azo]-, disodium saltFD&C Red no.40C.I. Food Red 17C. I. 16035Allura Red AC DyeDisodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfophenyl)azo)-2-naphthalenesulfonateDisodium 6-hydroxy-5-((6-methoxy-4-sulfo-m-tolyl)azo)-2-naphthalenesulfonateEINECS 247-368-0UNII-WZB9127XOAFancy RedJapan Food Red No. 40Japan Red 40

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 23 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - body paint - tattoo ink; Europe	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bubble bath	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
inert_ingredient; Pesticides	EPA	CPCat
general_foods	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Arts and crafts/Office supplies - body paint - tattoo ink; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
5.19	%	-	oral	dog	UnifiedCodex:SCCNFP:beta.noael_studies
500	mg/kg bw/day	-	oral	dog	UnifiedCodex:SCCNFP:beta.noael_studies
=700	mg/kg	-	oral	dog	UnifiedCodex:SCCNFP:beta.noael_studies
=700	mg/kg	-	oral	dog	UnifiedCodex:SCCNFP:beta.noael_studies
=700	mg/kg	-	oral	dog	UnifiedCodex:SCCNFP:beta.noael_studies
700	mg/kg bw/day	-	oral	-	UnifiedCodex:SCCNFP:beta.noael_studies
700	mg/kg	-	-	-	UnifiedCodex:SCCNFP:beta.noael_studies
3750	mg/kg bw/day	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
57.1229775240489	uM	AC50	-	-	NTP_ICE_endocrine
63.4118100206417	uM	ACC	-	-	NTP_ICE_endocrine
=0.14	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.14	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=7	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=7	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=7	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.14	mg/kg bw	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.14	mg/kg bw	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=16.4	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
WZB9127XOA	UNII	FDA UNII substance identifier	-	-	openFDA substances
WZB9127XOA	UNII	FDA UNII substance identifier	-	-	openFDA substances
WZB9127XOA	UNII	FDA UNII substance identifier	-	-	openFDA substances
WZB9127XOA	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0137	fraction	Fu	-	Human	NTP_ICE_adme_parameters
>10000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=50	mg/kg bw/day	LOAEL	-	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=50	mg/kg bw/day	LOAEL	-	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
250	mg/kg bw/day	LOAEL	oral	dog	COSMOS_DB
=545.68	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_HPVIS
>2829	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_HPVIS
=3604	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_HPVIS
=51900	ppm	LOAEL	oral	Rat	ToxValDB_HPVIS
=10	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0157	unitless	Model Score	-	-	NTP_ICE_endocrine
=1.39	%	NOAEL	oral	-	SCCNFP_vision_codex
=1.39	%	NOAEL	oral	-	SCCNFP_vision_codex
=1.39	%	NOAEL	oral	-	SCCNFP_vision_codex
=1.39	%	NOAEL	oral	-	SCCNFP_vision_codex
>5.19	% diet	NOAEL	oral	Mouse	ToxValDB_HPVIS
=5.19	%	NOAEL	oral	dog	SCCNFP_vision_codex
=5.19	%	NOAEL	oral	dog	SCCNFP_vision_codex
=5.19	%	NOAEL	oral	dog	SCCNFP_vision_codex
=5.19	%	NOAEL	oral	dog	SCCNFP_vision_codex
=7	mg/kg bw/day	NOAEL	oral	-	SCCNFP_vision_codex
=7	mg/kg bw/day	NOAEL	oral	-	SCCNFP_vision_codex
=7	mg/kg bw/day	NOAEL	oral	-	SCCNFP_vision_codex
=7	mg/kg bw/day	NOAEL	oral	-	SCCNFP_vision_codex
=10	mg/kg bw/day	NOAEL	oral: feed	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOAEL	oral: feed	Mouse	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate	247-368-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.4% (hair dye use only)

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3188816

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E129 — ADI: 7 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Allura Red C.I.16035?

Allura Red C.I.16035 has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Allura Red C.I.16035?

Allura Red C.I.16035 appears on 16 regulatory/inventory lists including Europe; Personal care - hair coloring, IFRA Transparency, inert_ingredient; non_food_use; Pesticides, and 13 more. Source: EPA CPDat.

Is Allura Red C.I.16035 used in cosmetics?

Yes, Allura Red C.I.16035 is also indexed as a cosmetic ingredient under the name CI 16035 (Allura Red AC). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Allura Red C.I.16035 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Allura Red C.I.16035 used outside industrial chemicals?

Allura Red C.I.16035 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.