What is the NOAEL for Gemfibrozil?
Gemfibrozil has 22 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
NOAEL Data
IARC Group 3
Prop 65
REACH Registered
Cosmetic Ingredient
Gemfibrozil
Also known as: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid, 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid, Genlip, Lipur, Lopid (+14 more)
CAS 25812-30-0
Gemfibrozil (CAS 25812-30-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: California Proposition 65, REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Gemfibrozil is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H361, H411, H301, H317, H318, H360D).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
18
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Gemfibrozil
CAS Number
25812-30-0
DTXSID
DTXSID0020652
Molecular Formula
C15H22O3
InChI Key
HEMJJKBWTPKOJG-UHFFFAOYSA-N
Monoisotopic Mass
250.156895
Synonyms
2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acidGenlipLipurLopidBRN 1881200EINECS 247-280-2Apo-GemfibrozilBolutolCholespidClearolElmogan
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1996 | 66 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
2 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
| - | female, male | No | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
PharmaceuticalNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
18 records
| List | Keyword | Source |
|---|---|---|
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| pharmaceutical | US International Trade Commission | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| detected; drinking_water | Illinois EPA | CPCat |
| detected; drinking_water | Illinois EPA | CPCat |
| detected; pharmaceutical; wastewater | USGS | United States Geological Survey (USGS) |
| detected; pharmaceutical; soil | USGS | United States Geological Survey (USGS) |
| detected; pharmaceutical; wastewater | Drinking Water Inspectorate | CPCat |
| detected; drinking_water; pharmaceutical | Drinking Water Inspectorate | CPCat |
| detected; MN Chemical Screening; pharmaceutical; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; pharmaceutical; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | NPS & EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FRcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRfemale, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 52.18 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| Q8X02027X3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8X02027X3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8X02027X3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q8X02027X3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.03 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =479 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1414 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| <30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Gemfibrozil | 247-280-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GEMFIBROZIL
ChEMBL Phase
4
Adverse Events
442
Bioactivity
15
Frequently Asked Questions
What regulatory lists include Gemfibrozil?
Gemfibrozil appears on 11 regulatory/inventory lists including detected; MN Chemical Screening; surface_water, pharmaceutical, OEHHA Proposition 65 (3/2019), and 8 more. Source: EPA CPDat.
Is Gemfibrozil a carcinogen according to IARC?
Gemfibrozil is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1996). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Gemfibrozil on the California Proposition 65 list?
Yes, Gemfibrozil is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Gemfibrozil used in cosmetics?
Yes, Gemfibrozil is also indexed as a cosmetic ingredient under the name Gemfibrozil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gemfibrozil come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Gemfibrozil have different safety status in cosmetics vs industrial chemicals?
Gemfibrozil is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H361, H411, H301, H317, H318, H360D).
Is Gemfibrozil used outside industrial chemicals?
Gemfibrozil also appears in cosmetics, pharmaceutical databases.