NOAEL Data REACH Registered Cosmetic Ingredient

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate

Also known as: Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol, 2,2,4-Trimethyl-1,3-neopentyl glycol monoisobutyrate, 2,2,4-Trimethyl-1,3-pentanediol mono(2-methylpropanoate), 2,2,4-Trimethyl-1,3-pentanediol monoisobutylate, 3-Pentanediol,2,2,4-trimethyl-monoisobutyrate (+12 more)

CAS 25265-77-4

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate (CAS 25265-77-4) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Trimethyl Hydroxypentyl Isobutyrate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate

CAS Number

25265-77-4

DTXSID

DTXSID5027857

Synonyms

Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol2,2,4-Trimethyl-1,3-neopentyl glycol monoisobutyrate2,2,4-Trimethyl-1,3-pentanediol mono(2-methylpropanoate)2,2,4-Trimethyl-1,3-pentanediol monoisobutylate3-Pentanediol,2,2,4-trimethyl-monoisobutyrateAlcohol ester 12Ester 12GRSHY 1800Nexcoat NX 795NX 795Acido propanoico, 2-metil-Monoacrilato de 2,2,4-trimetil-1 ,3-pentanediol2,2,4-trimethylpentane-1,3-diol isobutyrate

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and skin.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventPlasticizerSurfactant (surface active agent)BinderDiluentProcessing aids not otherwise specifiedFilm formerCoalescing agentNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
IFRA Transparency	IFRA	IFRA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
=123.42	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
ID6ZZH846Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
ID6ZZH846Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
ID6ZZH846Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
ID6ZZH846Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
=3200	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=27537.8	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
=1.3358	mg/m3	NOAEL (ADJ)	oral	Rat	ToxValDB_TX_TCEQ
=1035.4	mg/m3	NOAEL (ADJ)	inhalation	Rat	ToxValDB_TX_TCEQ
>15	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
>150	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol	246-771-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate?

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate has 13 NOAEL studies in the database. The lowest reported value is 123.42 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate?

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; plastic_additive, IFRA Transparency, and 2 more. Source: EPA CPDat.

Is 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate used in cosmetics?

Yes, 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate is also indexed as a cosmetic ingredient under the name Trimethyl Hydroxypentyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate used outside industrial chemicals?

2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate also appears in cosmetics databases.