What is the NOAEL for Dipropylene glycol?
Dipropylene glycol has 85 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dipropylene glycol
Also known as: Propanol, oxybis-, Dowanol DPG, Caswell No. 399E, EINECS 246-770-3, EPA Pesticide Chemical Code 068604 (+4 more)
CAS 25265-71-8
Dipropylene glycol (CAS 25265-71-8) is a chemical substance. Key regulatory status: REACH registered, 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
85
SOURCE
chemical inventory jurisdictions
Regulatory lists
35
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Dipropylene glycol
CAS Number
25265-71-8
DTXSID
DTXSID0027856
Synonyms
Propanol, oxybis-Dowanol DPGCaswell No. 399EEINECS 246-770-3EPA Pesticide Chemical Code 068604Oxybispropanol4-Oxa-2,6-heptandiol1,1'-Oxybis(2-propanol)UNII-E107L85C40
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSolubility enhancerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
35 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 85 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =238 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| E107L85C40 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E107L85C40 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E107L85C40 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E107L85C40 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =425 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =425 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =460 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =460 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =470 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =470 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =715 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =715 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1230 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1230 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1950 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1950 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2330 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =2330 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2390 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =2390 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2650 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =2650 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =5420 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =5420 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =10666.7 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =10666.7 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =14700 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =14700 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =8950 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =8950 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =11100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =11100 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =12800 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =12800 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =13000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =13000 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =115 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =115 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =530 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =530 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1040 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1040 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1220 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1220 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1450 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =1450 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =2860 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
Showing 50 of 85 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Oxydipropanol | 246-770-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
solvent
Frequently Asked Questions
What regulatory lists include Dipropylene glycol?
Dipropylene glycol appears on 15 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), and 12 more. Source: EPA CPDat.
Is Dipropylene glycol used in cosmetics?
Yes, Dipropylene glycol is also indexed as a cosmetic ingredient under the name DIPROPYLENE GLYCOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dipropylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Dipropylene glycol used outside industrial chemicals?
Dipropylene glycol also appears in cosmetics databases.