What is the NOAEL for Tolnaftate?
Tolnaftate has 5 NOAEL studies in the database. The lowest reported value is 06KB629TKV UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Tolnaftate
Also known as: BRN 2752620, Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester, Dermoxin, EINECS 219-266-6, Fungistop (+8 more)
CAS 2398-96-1
Tolnaftate (CAS 2398-96-1) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Tolnaftate
CAS Number
2398-96-1
DTXSID
DTXSID3042477
Molecular Formula
C19H17NOS
InChI Key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
Monoisotopic Mass
307.103085
Synonyms
BRN 2752620Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl esterDermoxinEINECS 219-266-6FungistopHI-AlazinTinavetTolnaftatumUNII-06KB629TKVMethyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl esterN-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamideO-2-Naphthyl m,N-dimethylthiocarbanilate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
BiocideNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 06KB629TKV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 06KB629TKV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 06KB629TKV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 06KB629TKV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >6000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TOLNAFTATE
ChEMBL Phase
3
Adverse Events
105
Bioactivity
8
Frequently Asked Questions
What regulatory lists include Tolnaftate?
Tolnaftate appears on 3 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.
Is Tolnaftate used in cosmetics?
Yes, Tolnaftate is also indexed as a cosmetic ingredient under the name Tolnaftate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tolnaftate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Tolnaftate used outside industrial chemicals?
Tolnaftate also appears in cosmetics, pharmaceutical databases.