What is the NOAEL for 4-Hydroxyindole?
4-Hydroxyindole has 4 NOAEL studies in the database. The lowest reported value is 1W4VD9085V UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Hydroxyindole
Also known as: EINECS 219-177-2, UNII-1W4VD9085V, hydroxyindoles
CAS 2380-94-1
4-Hydroxyindole (CAS 2380-94-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Hydroxyindole is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
4-Hydroxyindole
CAS Number
2380-94-1
DTXSID
DTXSID3057696
Molecular Formula
C8H7NO
InChI Key
NLMQHXUGJIAKTH-UHFFFAOYSA-N
Monoisotopic Mass
133.052764
Synonyms
EINECS 219-177-2UNII-1W4VD9085Vhydroxyindoles
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1W4VD9085V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W4VD9085V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W4VD9085V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1W4VD9085V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-hydroxyindole | 219-177-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL446571
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 4-Hydroxyindole?
4-Hydroxyindole appears on 2 regulatory/inventory lists including banned; Europe; Personal care, pharmaceutical. Source: EPA CPDat.
Is 4-Hydroxyindole used in cosmetics?
Yes, 4-Hydroxyindole is also indexed as a cosmetic ingredient under the name 4-Hydroxyindole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Hydroxyindole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Hydroxyindole have different safety status in cosmetics vs industrial chemicals?
4-Hydroxyindole is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Is 4-Hydroxyindole used outside industrial chemicals?
4-Hydroxyindole also appears in cosmetics, pharmaceutical databases.