What is the NOAEL for (Z)-Non-6-enal?
(Z)-Non-6-enal has 20 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(Z)-Non-6-enal
Also known as: 6-Nonenal, (6Z)-, BRN 2323664, EINECS 218-900-9, FEMA No. 3580, (Z)-6-Nonenal (+3 more)
CAS 2277-19-2
(Z)-Non-6-enal (CAS 2277-19-2) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
(Z)-Non-6-enal
CAS Number
2277-19-2
DTXSID
DTXSID4051879
Molecular Formula
C9H16O
InChI Key
RTNPCOBSXBGDMO-ARJAWSKDSA-N
Monoisotopic Mass
140.120115
Synonyms
6-Nonenal, (6Z)-BRN 2323664EINECS 218-900-9FEMA No. 3580(Z)-6-Nonenalcis-6-Nonenalcis-6-Nonen-1-alUNII-D8027Y6086
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5.1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 121.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 23 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 23 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 23 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 23 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| D8027Y6086 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D8027Y6086 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D8027Y6086 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D8027Y6086 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 381.6 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 9.786 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =127 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (Z)-non-6-enal | 218-900-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (Z)-Non-6-enal?
(Z)-Non-6-enal appears on 4 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product, and 1 more. Source: EPA CPDat.
Is (Z)-Non-6-enal used in cosmetics?
Yes, (Z)-Non-6-enal is also indexed as a cosmetic ingredient under the name cis-6-Nonenal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (Z)-Non-6-enal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (Z)-Non-6-enal used outside industrial chemicals?
(Z)-Non-6-enal also appears in cosmetics, food safety, cannabis databases.