What is the NOAEL for Aluminum hydroxide?
Aluminum hydroxide has 15 NOAEL studies in the database. The lowest reported value is 10.76 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Aluminum hydroxide
Also known as: Al(OH)3, Alum, Aluminum hydroxide (Al(OH)3), Aluminum(III) hydroxide, British aluminum AF 260 (+6 more)
CAS 21645-51-2
Aluminum hydroxide (CAS 21645-51-2) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Aluminum hydroxide
CAS Number
21645-51-2
DTXSID
DTXSID2036405
Molecular Formula
Al.3H2O
InChI Key
WNROFYMDJYEPJX-UHFFFAOYSA-K
Monoisotopic Mass
81.013233
Synonyms
Al(OH)3AlumAluminum hydroxide (Al(OH)3)Aluminum(III) hydroxideBritish aluminum AF 260EINECS 244-492-7MartinalTrihydrated aluminaAlugelibyeUNII-5QB0T2IUN0Aluminum hydroxide, dried
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
HumectantSoftener and conditionerViscosity modifierOpaciferDyePigmentFlame retardantFiller
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10.76 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5QB0T2IUN0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QB0T2IUN0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QB0T2IUN0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5QB0T2IUN0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| =92 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =266 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aluminium hydroxide | 244-492-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
Category-specific elemental aluminum limits per SCCS/1662/23
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ALUMINUM HYDROXIDE
ChEMBL Phase
4
Adverse Events
888
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Aluminum hydroxide?
Aluminum hydroxide appears on 9 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; animal_products; Europe; pharmaceutical; residue, Europe; plastic_additive, and 6 more. Source: EPA CPDat.
Is Aluminum hydroxide used in cosmetics?
Yes, Aluminum hydroxide is also indexed as a cosmetic ingredient under the name Aluminum Hydroxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Aluminum hydroxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Aluminum hydroxide used outside industrial chemicals?
Aluminum hydroxide also appears in cosmetics, pharmaceutical, cannabis databases.