What is the NOAEL for 2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate?
2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate has 8 NOAEL studies in the database. The lowest reported value is 35 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate
Also known as: Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl ester, Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester, 2-[Methacryloyloxy]ethyl acetoacetate, 2-(Acetoacetoxy)ethyl methacrylate, EINECS 244-311-1 (+3 more)
CAS 21282-97-3
2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate (CAS 21282-97-3) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Acetoacetoxyethoxy Methacrylate →
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate
CAS Number
21282-97-3
DTXSID
DTXSID7041388
Molecular Formula
C10H14O5
InChI Key
IBDVWXAVKPRHCU-UHFFFAOYSA-N
Monoisotopic Mass
214.084124
Synonyms
Butanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl esterButanoic acid, 3-oxo-, 2-((2-methyl-1-oxo-2-propenyl)oxy)ethyl ester2-[Methacryloyloxy]ethyl acetoacetate2-(Acetoacetoxy)ethyl methacrylateEINECS 244-311-12-(Methacryloyloxy)ethyl acetoacetateUNII-6L3EW3HZF2Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Film formerChemical reaction regulator
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =35 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6L3EW3HZF2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3EW3HZF2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3EW3HZF2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3EW3HZF2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-[(2-methyl-1-oxoallyl)oxy]ethyl acetoacetate | 244-311-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188313
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate used in cosmetics?
Yes, 2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate is also indexed as a cosmetic ingredient under the name Acetoacetoxyethoxy Methacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate used outside industrial chemicals?
2-((2-Methyl-1-oxoallyl)oxy)ethyl acetoacetate also appears in cosmetics, pharmaceutical databases.