What is the NOAEL for 2-Ethylhexyl 4-(dimethylamino)benzoate?
2-Ethylhexyl 4-(dimethylamino)benzoate has 17 NOAEL studies in the database. The lowest reported value is 0 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl 4-(dimethylamino)benzoate
Also known as: 2-Ethylhexyl-p-dimethyl-aminobenzoate, EINECS 244-289-3, UNII-Z11006CMUZ
CAS 21245-02-3
2-Ethylhexyl 4-(dimethylamino)benzoate (CAS 21245-02-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Padimate O (Ethylhexyl Dimethyl PABA) →
Cross-Vertical Regulatory Divergence
2-Ethylhexyl 4-(dimethylamino)benzoate is classified GHS Danger (H315, H319, H335, H360F) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
2-Ethylhexyl 4-(dimethylamino)benzoate
CAS Number
21245-02-3
DTXSID
DTXSID7029320
Molecular Formula
C17H27NO2
InChI Key
WYWZRNAHINYAEF-UHFFFAOYSA-N
Monoisotopic Mass
277.204179
Synonyms
2-Ethylhexyl-p-dimethyl-aminobenzoateEINECS 244-289-3UNII-Z11006CMUZ
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
UV stabilizerPhotosensitizersChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8.92030686234856 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 9.19961177346848 | uM | ACC | - | - | NTP_ICE_endocrine |
| =3.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| - | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| Z11006CMUZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z11006CMUZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z11006CMUZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z11006CMUZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2.77e-8 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.04 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0114 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =100 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| - | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexyl 4-(dimethylamino)benzoate | 244-289-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PADIMATE O
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl 4-(dimethylamino)benzoate?
2-Ethylhexyl 4-(dimethylamino)benzoate appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Canada; pharmaceutical, Europe; Personal care. Source: EPA CPDat.
Is 2-Ethylhexyl 4-(dimethylamino)benzoate used in cosmetics?
Yes, 2-Ethylhexyl 4-(dimethylamino)benzoate is also indexed as a cosmetic ingredient under the name Padimate O (Ethylhexyl Dimethyl PABA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl 4-(dimethylamino)benzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethylhexyl 4-(dimethylamino)benzoate have different safety status in cosmetics vs industrial chemicals?
2-Ethylhexyl 4-(dimethylamino)benzoate is classified GHS Danger (H315, H319, H335, H360F) in the chemicals database but is allowed in EU cosmetics.
Is 2-Ethylhexyl 4-(dimethylamino)benzoate used outside industrial chemicals?
2-Ethylhexyl 4-(dimethylamino)benzoate also appears in cosmetics, pharmaceutical, cannabis databases.