What is the NOAEL for Berberine?
Berberine has 4 NOAEL studies in the database. The lowest reported value is 0I8Y3P32UF UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Berberine
Also known as: EC No.: 218-229-1, BRN 3570374, 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium, EINECS 218-229-1, UNII-0I8Y3P32UF (+6 more)
CAS 2086-83-1
Berberine (CAS 2086-83-1) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Berberine
CAS Number
2086-83-1
DTXSID
DTXSID9043857
Molecular Formula
C20H18NO4
InChI Key
YBHILYKTIRIUTE-UHFFFAOYSA-N
Monoisotopic Mass
336.123583
Synonyms
EC No.: 218-229-1BRN 35703749,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbiniumEINECS 218-229-1UNII-0I8Y3P32UF16,17-dimethoxy-5,7-dioxa-13l5-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-13-ylium7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-[methylenebis(oxy)]berbinium9,10-dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetradehydroberbiniumBenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-BerberalCoptis rhizome
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0I8Y3P32UF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0I8Y3P32UF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0I8Y3P32UF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0I8Y3P32UF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BERBERINE
ChEMBL Phase
4
Adverse Events
380
Bioactivity
10
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Berberine?
Berberine appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Berberine used in cosmetics?
Yes, Berberine is also indexed as a cosmetic ingredient under the name Berberine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Berberine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Berberine used outside industrial chemicals?
Berberine also appears in cosmetics, pharmaceutical, food safety databases.