What is the NOAEL for POLYSILICONE-15?
POLYSILICONE-15 has 21 NOAEL studies in the database. The lowest reported value is F8DRP5BB29 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
POLYSILICONE-15
CAS 207574-74-1
POLYSILICONE-15 (CAS 207574-74-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
POLYSILICONE-15 is classified GHS Danger (H330, H413) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
21
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
3 fields
Name
POLYSILICONE-15
CAS Number
207574-74-1
DTXSID
DTXSID701042777
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
UV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| F8DRP5BB29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F8DRP5BB29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F8DRP5BB29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F8DRP5BB29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.6 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.6 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.6 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.6 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.6 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =1000 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =1000 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethicodiethylbenzalmalonate | 426-000-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1403/10 | 22 June 2010 | safe with restrictions | up to 10% | Acute inhalation toxicity data submitted and evaluated; dermally applied cosmetics safe at 10%; subsequent regulatory review of spray use recommended |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
sunscreen
Frequently Asked Questions
What regulatory lists include POLYSILICONE-15?
POLYSILICONE-15 appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is POLYSILICONE-15 used in cosmetics?
Yes, POLYSILICONE-15 is also indexed as a cosmetic ingredient under the name Polysilicone-15. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for POLYSILICONE-15 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does POLYSILICONE-15 have different safety status in cosmetics vs industrial chemicals?
POLYSILICONE-15 is classified GHS Danger (H330, H413) in the chemicals database but is allowed in EU cosmetics.
Is POLYSILICONE-15 used outside industrial chemicals?
POLYSILICONE-15 also appears in cosmetics databases.