What is the NOAEL for Monosodium citrate?
Monosodium citrate has 7 NOAEL studies in the database. The lowest reported value is 68538UP9SE UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Monosodium citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:1), 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monosodium salt, Citric acid, monosodium salt, Sodium citrate (NaC6H7O7), Citrofluyl (+5 more)
CAS 18996-35-5
Monosodium citrate (CAS 18996-35-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Monosodium citrate
CAS Number
18996-35-5
DTXSID
DTXSID80872904
Molecular Formula
C6H8O7.Na
InChI Key
HWPKGOGLCKPRLZ-UHFFFAOYSA-M
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:1)1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monosodium saltCitric acid, monosodium saltSodium citrate (NaC6H7O7)CitrofluylE 331iMonosodium dihydrogen citrateSodium dihydrogen citratePROPANE-1,2,3-TRICARBOXYLATE, 2-HYDROXY-, MONOSODIUME 331 (i)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
pH regulating agentFragranceProcessing aids not otherwise specifiedDegradant/impurityChelating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 68538UP9SE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68538UP9SE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68538UP9SE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68538UP9SE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =8.9 | % diet | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =5 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium dihydrogen citrate | 242-734-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E331i — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Monosodium citrate?
Monosodium citrate appears on 5 regulatory/inventory lists including IFRA Transparency, inert_ingredient; Pesticides, Indirect additives food contact (10/2018), and 2 more. Source: EPA CPDat.
Is Monosodium citrate used in cosmetics?
Yes, Monosodium citrate is also indexed as a cosmetic ingredient under the name Monosodium Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Monosodium citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Monosodium citrate used outside industrial chemicals?
Monosodium citrate also appears in cosmetics, food safety databases.